Prolonged poststimulation inhibition of bladder activity induced by tibial nerve stimulation in cats
Prolonged poststimulation inhibition of bladder activity induced by tibial nerve stimulation in cats
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DOI：
10.1152/ajprenal.00526.2010
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发表时间：
2011-02-01
影响因子：
4.2
通讯作者：
de Groat, William C.
中科院分区：
文献类型：
--
作者：
Tai, Changfeng;Shen, Bing;de Groat, William C.
戴超，沈波，陈敏，王杰，Roppolo JR, de Groat WC。猫胫骨神经刺激后膀胱活动的长期抑制。[J]中华医学杂志，2011；doi: 10.1152 / ajprenal.00526.2010。-研究了对脊髓完整的-氯氯糖麻醉猫的胫骨神经刺激对膀胱活动的抑制作用。短时间（3-5分钟）低（5赫兹）和高（30赫兹）频率的胫骨神经刺激在节律性等容量膀胱收缩期间反复应用，可有效抑制膀胱反射活动。两种频率的刺激在诱导抑制方面也都是有效的，这种抑制在刺激结束后仍然存在。短时间刺激引起的刺激后抑制作用使膀胱容量显著增加，达到刺激前对照组容量的181.6 +/- 24.36%。连续刺激30分钟后，膀胱活动抑制时间延长，持续时间超过2小时，膀胱容量显著增加，为对照组的161.1 +/- 2.9%。在刺激后阶段，膀胱电图期间施加的5 hz刺激引起膀胱容量进一步增加（平均约30%），但30 hz刺激无效。这些在猫身上的结果支持了临床观察，即胫骨神经调节诱导持久的刺激后抑制作用，这对治疗膀胱过度活跃症状是有用的。
Tai C, Shen B, Chen M, Wang J, Roppolo JR, de Groat WC. Prolonged poststimulation inhibition of bladder activity induced by tibial nerve stimulation in cats. Am J Physiol Renal Physiol 300: F385-F392, 2011; doi:10.1152/ajprenal.00526.2010.-Inhibition of bladder activity by tibial nerve stimulation was investigated in alpha-chloralose-anesthetized cats with an intact spinal cord. Short-duration (3-5 min) tibial nerve stimulation at both low (5 Hz) and high (30 Hz) frequencies applied repeatedly during rhythmic isovolumetric bladder contractions was effective in inhibiting reflex bladder activity. Both frequencies of stimulation were also effective in inducing inhibition that persisted after the termination of the stimulation. The poststimulation inhibitory effect induced by the short-duration stimulation significantly increased bladder capacity to 181.6 +/- 24.36% of the control capacity measured before applying the stimulation. Thirty-minute continuous stimulation induced prolonged poststimulation inhibition of bladder activity, which lasted for more than 2 h and significantly increased bladder capacity to 161.1 +/- 2.9% of the control capacity. During the poststimulation periods, 5-Hz stimulation applied during the cystometrogram elicited a further increase (similar to 30% on average) in bladder capacity, but 30-Hz stimulation was ineffective. These results in cats support the clinical observation that tibial nerve neuromodulation induces a long-lasting poststimulation inhibitory effect that is useful in treating overactive bladder symptoms.