Increased frequencies of T helper type 17 cells in the peripheral blood of patients with acute myeloid leukaemia
Increased frequencies of T helper type 17 cells in the peripheral blood of patients with acute myeloid leukaemia
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急性髓性白血病患者外周血中 17 型辅助 T 细胞频率增加
DOI：
10.1111/j.1365-2249.2009.04011.x
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发表时间：
2009-11-01
影响因子：
4.6
通讯作者：
Xu, H.
中科院分区：
文献类型：
--
作者：
Wu, C.;Wang, S.;Xu, H.
辅助性T细胞17型（Th 17）是CD 4 + T细胞的一个新的亚群，在炎症和自身免疫性疾病中起着积极的作用。最近的研究还表明，它们对实体瘤有影响。然而，Th 17细胞在血液系统恶性肿瘤中的性质仍然未知。在这项研究中，我们调查了急性髓性白血病（AML）患者的Th 17细胞频率和相关细胞因子的分泌。首先，我们发现与健康志愿者相比，未经治疗的AML患者外周血样本中Th 17细胞频率显著增加。此外，白细胞介素（IL）-17浓度增加伴随着这些患者中Th 17细胞频率的增加。提示Th 17细胞可能在AML的发病机制中起一定作用。其次，我们发现当患者化疗后达到完全缓解时，升高的Th 17细胞频率降低，提示检测Th 17细胞频率可能对评价治疗效果具有临床价值。此外，我们发现未经治疗的患者中IL-6和转化生长因子（TGF）-β 1浓度升高，并且IL-6浓度与Th 17细胞频率呈正相关，表明IL-6可能在Th 17细胞分化中发挥重要作用。急性髓细胞白血病患者。
P>T helper type 17 (Th17) cells, which represent a novel subset of CD4+ T cells, play an active role in inflammatory and autoimmune diseases. Recent studies have also suggested that they have an impact on solid tumours. However, the nature of Th17 cells in haematological malignancies remains unknown. In this study, we investigated Th17 cell frequency and secretion of related cytokines in patients with acute myeloid leukaemia (AML). First, we found that Th17 cell frequencies were increased significantly in peripheral blood samples from untreated patients with AML, compared with those from healthy volunteers. Moreover, increased interleukin (IL)-17 concentrations accompanied the increased Th17 cell frequencies in these patients. These results suggest that Th17 cells may play a role in the pathogenesis of AML. Secondly, we found that the increased Th17 cell frequencies were reduced when patients achieved complete remission after chemotherapy, suggesting that measurement of Th17 cell frequencies may have clinical value in the evaluation of therapeutic effect. In addition, we found that IL-6 and transforming growth factor (TGF)-beta 1 concentrations increased in the untreated patients and that IL-6 concentrations showed a positive correlation with the frequencies of Th17 cells, suggesting that IL-6 may play an important role in Th17 cell differentiation in patients with AML.