Reproductive hormones in the early menopausal transition: Relationship to ethnicity, body size, and menopausal status
Reproductive hormones in the early menopausal transition: Relationship to ethnicity, body size, and menopausal status
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DOI：
10.1210/jc.2002-020777
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发表时间：
2003-04-01
影响因子：
5.8
通讯作者：
Lasley, BL
中科院分区：
文献类型：
--
作者：
Randolph, JF;Sowers, M;Lasley, BL
我们测量了社区多种族绝经前和围绝经早期妇女的血清生殖激素浓度，以确定激素是否存在可以用宿主因素解释的种族差异。我们在 7 个临床中心对全国女性健康研究的 2930 名参与者进行了研究，这些参与者年龄在 42-52 岁之间，自认为是非洲裔美国人 (27.6%)、白人 (47.1%)、中国人 (7.4%)、西班牙裔 (8.8%) 或日本人 (9.0%)。纵向研究基线评估的结果指标是血清雌二醇 (E2)、FSH、睾酮 (T)、硫酸脱氢表雄酮和 SHBG 浓度，以及主要在自发月经周期的早期卵泡期收集的血清中计算出的游离类固醇可用性、游离睾酮指数和游离 E2 指数的估计值。主要解释变量是种族/民族、绝经状态、年龄、体重指数、周期日期、吸烟、饮酒和体力活动。与其他族裔群体相比，中国女性未经调整的 E2 和性激素结合球蛋白 (SHBG) 水平较低，西班牙裔女性未经调整的 T 水平较低。未调整的血清 FSH 水平不因种族/民族而异。根据宿主特征（特别是体型）调整的 E2 水平不会因种族/民族而存在差异。非裔美国人和西班牙裔女性的调整后 FSH 水平较高，调整后 T 水平较低。血清 E2 和 FSH 浓度变化很大。血清 FSH 水平与绝经状态呈正相关，但没有其他激素浓度。血清硫酸脱氢表雄酮水平与年龄呈负相关，但与绝经状态无关。所有激素浓度均与体重指数显着相关。我们得出的结论是，血清性类固醇、FSH 和 SHBG 水平因种族而异，但与种族体型差异高度混淆。
We measured serum reproductive hormone concentrations in a community-based, multiethnic population of premenopausal and early perimenopausal women to determine whether there are ethnic differences in hormones that can be explained by host factors. We studied 2930 participants in the Study of Women's Health Across the Nation who were aged 42-52 yr and self-identified as African-American (27.6%), Caucasian (47.1%), Chinese (7.4%), Hispanic (8.8%), or Japanese (9.0%) at 7 clinical sites. Outcome measures from this baseline assessment of a longitudinal study were serum estradiol (E2), FSH, testosterone (T), dehydroepiandrosterone sulfate, and SHBG concentrations and calculated estimates of free steroid availability, free testosterone index, and free E2 index from serum collected primarily in the early follicular phase of a spontaneous menstrual cycle. The primary explanatory variables were race/ethnicity, menopausal status, age, body mass index, day of the cycle, smoking, alcohol use, and physical activity. Chinese women had lower unadjusted E2 and SHBG levels, and Hispanic women had lower unadjusted T levels than other ethnic groups. Unadjusted serum FSH levels did not differ by race/ethnicity. E2 levels adjusted for host characteristics, particularly body size, did not differ by race/ethnicity. Adjusted FSH levels were higher, and adjusted T levels were lower in African-American and Hispanic women. Serum E2 and FSH concentrations were highly variable. Serum FSH levels, but no other hormone concentrations, were positively correlated with menopausal status. Serum dehydroepiandrosterone sulfate levels were negatively correlated with age, but not menopausal status. All hormone concentrations were significantly correlated with body mass index. We conclude that serum sex steroid, FSH, and SHBG levels vary by ethnicity, but are highly confounded by ethnic disparities in body size.