Roles of Epithelial-Mesenchymal Transition in Squamous Cell Carcinoma of the Temporal Bone
Roles of Epithelial-Mesenchymal Transition in Squamous Cell Carcinoma of the Temporal Bone
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DOI：
10.1097/mao.0b013e31820d9654
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发表时间：
2011-04
影响因子：
2.1
通讯作者：
H. Sugimoto;Makoto Ito;M. Hatano;S. Kondo;Shioto Suzuki;T. Yoshizaki
中科院分区：
文献类型：
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作者：
H. Sugimoto;Makoto Ito;M. Hatano;S. Kondo;Shioto Suzuki;T. Yoshizaki
目的：作者最近证实，广泛的骨侵蚀与颞骨鳞状细胞癌(SCC)预后不良相关。本研究的目的是探讨上皮间充质转化(EMT)在颞骨鳞状细胞癌中的表达及其作用。研究设计：回顾患者档案，对患者颞骨鳞状细胞癌组织进行免疫组织化学研究。患者：应用免疫组织化学方法检测16例颞骨鳞状细胞癌组织中波形蛋白的表达。结果：如预期的那样，波形蛋白在颞骨鳞状细胞癌中有表达。我们认为具有波形蛋白阳性细胞的患者为EMT阳性患者，因为在几种类型的癌症中，波形蛋白的获得是EMT的一个标志。EMT阳性肿瘤与广泛骨侵蚀显著相关，广泛骨侵蚀与颞骨SCC预后不良相关。结论：本研究结果提示，肿瘤细胞中的EMT可作为判断颞骨鳞状细胞癌预后不良的重要指标。
Objectives: The authors recently demonstrated that extensive bone erosion correlated with a worse prognosis of the squamous cell carcinoma (SCC) of the temporal bone. The present objective was to investigate the expressions and the roles of epithelial-mesenchymal transition (EMT) in SCC of the temporal bone. Study Design: Retrospective patient file review and immunohistochemical study of tissues of patients with SCC of the temporal bone. Patients: The authors examined the expressions of vimentin in 16 patients with SCC of the temporal bone by immunohistochemical analysis. Results: As expected, vimentin was expressed on SCC of the temporal bone. We regard the patient who has vimentin-positive cells as EMT-positive patient because gain of vimentin is a hallmark in the EMT reported in several types of cancer. EMT positive tumors significantly correlated with extensive bone erosion, and extensive bone erosion correlated with a worse prognosis of the SCC of the temporal bone. Conclusion: The study results suggest that EMT in tumor cells becomes an important indicator of poor prognosis in SCC of the temporal bone.