Trypanosoma cruzi Journey from the Insect Vector to the Host Cell
Trypanosoma cruzi Journey from the Insect Vector to the Host Cell
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DOI：
10.1007/978-3-030-00054-7_2
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发表时间：
2019-01-01
期刊：
影响因子：
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通讯作者：
Gonzalez Cappa, Stella Maris
中科院分区：
文献类型：
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作者：
Alba Soto, Catalina D.;Gonzalez Cappa, Stella Maris
克氏锥虫是恰加斯病的病原体，它与哺乳动物细胞和昆虫媒介肠道之间形成了复杂的相互作用。在这些环境之间的旅程中，它会遭受压力变化。为了克服它们，寄生虫使用多种策略。不同的阶段接触宿主和载体的不同区室，从而确保生存和繁殖。表面蛋白（一些在原生动物的特定阶段被识别）对于与环境的相互作用至关重要，尽管许多人尚未完全理解它们的相关性。寄生虫分子允许克氏锥虫在载体肠道中生长、复制和分化，从而成为哺乳动物的感染阶段。表面分子还允许寄生虫穿过哺乳动物的细胞内基质到达细胞，并在识别后侵入细胞并适应生存，但也繁殖并分化为循环锥鞭毛体，从而确保生命周期的连续性。在本章中，我们总结了人类和其他感染宿主的克氏锥虫途径，以及不同克氏锥虫谱系在地理分布和人类疾病中的参与。最后，我们回顾了迄今为止描述的寄生虫到达、进入宿主细胞并在宿主细胞内生存的一些机制。
Trypanosoma cruzi, etiological agent of Chagas disease, has evolved a complex interaction with mammalian cells and insect vector's intestine. During its journey between these environments, it is subject to stressful changes. To overcome them, parasites use numerous strategies. Different stages contact diverse compartments of hosts and vectors thus assuring survival and multiplication. Surface proteins, some identified in particular stages of the protozoan, are critical for interaction with the milieu although their relevance is not totally understood for many. Parasite molecules allow T. cruzi to progress in the vector intestine, to duplicate and differentiate in order to become the infective stage for mammals. Surface molecules also allow parasites to advance through intracellular matrix of the mammals to reach the cells and, after recognition, invade them and adapt to survive but also to multiply and differentiate to circulating trypomastigotes thus assuring life cycle continuity. In this chapter we summarize T. cruzi pathways of humans and other reservoirs of infection as well as the participation of different T. cruzi lineages in geographical distribution and human disease. Finally, we review some of the mechanisms used by the parasite to reach, enter, and survive inside the host cell described so far.