Field induced fragmentation spectra from reactive stage-tandem differential mobility spectrometry
Field induced fragmentation spectra from reactive stage-tandem differential mobility spectrometry
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反应级串联差分迁移率光谱法的场诱导碎裂光谱
DOI：
10.1039/d0an00665c
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Eiceman, G. A.
中科院分区：
文献类型：
--
作者：
Fowler, P. E.;Pilgrim, J. Z.;Lee, G.;Eiceman, G. A.
将平面串联差分迁移率谱仪与中间反应阶段集成在一起，利用特征补偿和分离场对第一分析阶段选择的迁移率进行碎片化。在环境压力为660 Torr (8.8 kPa)，电场为10至35 kV cm - 1 （E/N为52至180 Td）的空气中，在位于第一和第二流动阶段之间的每个分析板上的两条1 mm宽的金属条之间发生破碎。在最后阶段，通过表征43种含氧挥发性有机化合物的质子化单体碎片离子的迁移率，产生了场诱导碎片（FIF）光谱。当醇类、醛类和醚类发生多步裂解时，裂解程度与E/N成正比；醋酸酯只分裂成一个离子，质子化乙酸。相反，酮类只有甲基i-丁基酮和2-己酮发生断裂。质量分析和已知的碎片路径支持了碎片离子的身份，并表明在环境压力下场诱导碎片可以将结构信息引入FIF光谱，为利用迁移率方法进行化学鉴定奠定了基础。
A planar tandem differential mobility spectrometer was integrated with a middle reactive stage to fragment ions which were mobility selected in a first analyzer stage using characteristic compensation and separation fields. Fragmentation occurred in air at ambient pressure of 660 Torr (8.8 kPa) with electric fields of 10 to 35 kV cm−1 (E/N of 52 to 180 Td) between two 1 mm wide metal strips, located on each analyzer plate between the first and second mobility stages. Field induced fragmentation (FIF) spectra were produced by characterizing, in a last stage, the mobilities of fragment ions from protonated monomers of 43 oxygen-containing volatile organic compounds from five chemical classes. The extent of fragmentation was proportional to E/N with alcohols, aldehydes, and ethers undergoing multiples steps of fragmentation; acetates fragmented only to a single ion, protonated acetic acid. In contrast, fragmentation of ketones occurred only for methyl i-butyl ketone and 2-hexanone. Fragment ion identities were supported by mass-analysis and known fragmentation routes and suggested that field induced fragmentation at ambient pressure can introduce structural information into FIF spectra, establishing a foundation for chemical identification using mobility methods.