EXPERIMENTAL OSTEOMYELITIS - DESCRIPTION OF A CANINE MODEL AND THE ROLE OF DEPOT ADMINISTRATION OF ANTIBIOTICS IN THE PREVENTION AND TREATMENT OF SEPSIS
EXPERIMENTAL OSTEOMYELITIS - DESCRIPTION OF A CANINE MODEL AND THE ROLE OF DEPOT ADMINISTRATION OF ANTIBIOTICS IN THE PREVENTION AND TREATMENT OF SEPSIS
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DOI：
10.2106/00004623-198365030-00013
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发表时间：
1983-01-01
影响因子：
5.3
通讯作者：
FITZGERALD, RH
中科院分区：
文献类型：
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作者：
FITZGERALD, RH
通过在由丙烯酸骨水泥组成的髓内异物周围滴注金黄色葡萄球菌悬液，在犬中持续产生胫骨近端部分的骨髓炎。感染过程的临床、组织学和X线表现与亚急性骨髓炎一致，如全关节置换术后感染。即使在取出丙烯酸骨水泥后，7例患者中有6例的骨髓炎过程仍持续存在。使用该模型，庆大霉素浸渍的丙烯酸骨水泥（Palacos）预防了同时暴露于S.金黄色葡萄球菌的浓度范围为1 × 1000 - 10000 μ g/ml。103比1 ×109个生物体。Palacos散装治疗S.金黄色葡萄球菌已经建立。
Osteomyelitis of the proximal portion of the tibia was consistently produced in the dog by the instillation of a suspension of Staphylococcus aureus about an intramedullary foreign body consisting of acrylic bone cement. The clinical, histological and roentgenographic manifestations of the infectious process were consistent with those of subacute osteomyelitis, such as may be encountered in infections following total joint arthroplasty. The osteomyelitic process persisted in 6 of the 7 tibiae even after removal of the acrylic bone cement. Using this model, gentamicin-impregnated acrylic bone cement (Palacos) prevented the development of osteomyelitis in 9 of 10 tibia that were concomitantly exposed to S. aureus in concentrations ranging from 1 .times. 103 to 1 .times. 109 organisms. Palacos in bulk form was ineffective in the treatment of 3 of 5 tibia in which osteomyelitis caused by S. aureus was already established.