Eucapsitrione, an anti-Mycobacterium tuberculosis anthraquinone derivative from the cultured freshwater cyanobacterium Eucapsis sp.
Eucapsitrione, an anti-Mycobacterium tuberculosis anthraquinone derivative from the cultured freshwater cyanobacterium Eucapsis sp.
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Eucapsitrione，一种抗结核分枝杆菌蒽醌衍生物，来自培养的淡水蓝藻 Eucapsis sp。
DOI：
10.1021/np100299v
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发表时间：
2010
影响因子：
5.1
通讯作者：
Orjala,Jimmy
中科院分区：
文献类型：
--
作者：
Sturdy,Megan;Krunic,Aleksej;Cho,Sanghyun;Franzblau,Scott;Orjala,Jimmy
Eucapsitrione (1) 是一种具有茚并蒽三酮骨架的蒽醌衍生物，是从蓝细菌 Eucapsissp 中分离出来的。 (UTEX 1519) 通过生物测定引导的分级分离。通过分析 MS 以及 1D 和 2D NMR 光谱数据确定化学结构。 Eucapsitrione (1) 在微孔板阿尔马尔蓝测定和低氧回收测定中显示出抗结核分枝杆菌活性，MIC 值分别为 3.1 和 6.4 μM。
Eucapsitrione (1), an anthraquinone derivative with an indeno-anthracene-trione skeleton, was isolated from the cyanobacteriumEucapsissp. (UTEX 1519) by bioassay-guided fractionation. The chemical structure was determined by analyzing MS and 1D and 2D NMR spectroscopic data. Eucapsitrione (1) showed anti-Mycobacterium tuberculosisactivity in the microplate Alamar blue assay and low-oxygen-recovery assay with MIC values of 3.1 and 6.4 μM, respectively.