HUMORAL IMMUNE-RESPONSE TO ALLOGRAFTS OF BONE
HUMORAL IMMUNE-RESPONSE TO ALLOGRAFTS OF BONE
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DOI：
10.1159/000231262
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发表时间：
1974-01-01
期刊：
影响因子：
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通讯作者：
ELVES, MW
中科院分区：
文献类型：
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作者：
ELVES, MW
已经对接受 Ag-B 不同皮质骨或松质骨同种异体移植物的大鼠体内细胞毒性抗体的产生进行了研究。结果表明，含有骨髓的松质移植物引起的抗体产生模式与皮肤移植后的抗体产生模式非常相似。相比之下，对皮内注射的同种异体脾细胞的反应更快。无骨髓松质骨或皮质骨移植物会产生延迟发作的抗体反应。用 X 射线处理的新鲜移植物或通过冷冻或冻干保存的移植物无法引起任何抗体产生。与主要 Ag-B 抗原系统的宿主相同的移植物也无法引发体液免疫反应。讨论了这些发现的意义。
A study of production of cytotoxic antibodies in rats receiving Ag-B disparate cortical or cancellous bone allografts has been made. The results indicate that marrow-containing cancellous grafts elicit a pattern of antibody production which is very similar to that following skin grafts. In contrast, the response to allogeneic spleen cells injected intradermally is more rapid. Grafts of marrow-free cancellous or cortical bone give rise to an antibody response which is delayed in onset. Fresh grafts treated with X-irradiation or grafts preserved by freezing or freeze-drying fail to elicit any antibody production. Grafts which are identical with the host for the major Ag-B antigen system also fail to elicit a humoral immune response. The significance of these findings is discussed.