Risk factors for cardiovascular disease in women with a history of pregnancy complicated by preeclampsia or intrauterine growth restriction
Risk factors for cardiovascular disease in women with a history of pregnancy complicated by preeclampsia or intrauterine growth restriction
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DOI：
10.1080/10641950601146574
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发表时间：
2007-01-01
影响因子：
1.5
通讯作者：
Franx, Arie
中科院分区：
文献类型：
--
作者：
Manten, Gwendolyn T. R.;Sikkema, Marko J.;Franx, Arie
目的：有先兆子痫或宫内生长受限(IUGR)病史的女性在晚年患心血管疾病的风险增加。我们确定了传统的和新的心血管疾病危险因素在这些女性中的存在。方法：我们研究了256名有先兆子痫病史的妇女和59名有宫内发育受限史的妇女。53名有无并发症孕产史的女性作为对照。我们测定了血压、体重指数、胆固醇、高密度脂蛋白胆固醇、甘油三酯和脂蛋白(A)的浓度，以及胰岛素抵抗。结果：与无并发症妊娠史的妇女相比，有先兆子痫史的妇女显示出更多的未来心血管疾病的危险因素，如血脂异常、高血压、肥胖和胰岛素抵抗增加。与有正常孕产史的妇女相比，有IUGR病史的妇女有更高的胆固醇浓度，并表现出更高的BMI、更高的甘油三酯浓度和更高的胰岛素抵抗。结论：子痫前期或IUGR可能是早期心血管疾病风险增加的早期标志。
Objective: Women with a history of preeclampsia or intrauterine growth restriction (IUGR) have an increased risk for cardiovascular disease in later life. We determined the presence of traditional and novel risk factors for cardiovascular disease in these women. Methods: We studied 256 women with a history of preeclampsia and 59 women with a history of intrauterine growth restriction. Fifty-three women with a history of uncomplicated pregnancy served as controls. We determined values for blood pressure, body mass index, concentrations of cholesterol, high-density lipoprotein cholesterol, triglycerides and lipoprotein (a), and insulin resistance. Results: Women with a history of preeclampsia exhibited more risk factors for future cardiovascular disease such as dyslipidemia, hypertension, obesity, and increased insulin resistance compared with women with a history of uncomplicated pregnancy. Women with a history of IUGR have higher concentrations of cholesterol and show a tendency to higher BMI, higher triglyceride concentrations, and increased insulin resistance as compared with women with a history of normal pregnancy. Conclusions: Preeclampsia or IUGR may represent an early marker for increased risk for early cardiovascular disease.