Homeobox genes in the rodent pineal gland: roles in development and phenotype maintenance.
Homeobox genes in the rodent pineal gland: roles in development and phenotype maintenance.
复制标题
啮齿动物松果体中的同源框基因：在发育和表型维持中的作用。
DOI：
10.1007/s11064-012-0906-y
复制
发表时间：
2013
影响因子：
4.4
通讯作者：
Møller,Morten
中科院分区：
文献类型：
--
作者：
Rath,MartinF;Rohde,Kristian;Klein,DavidC;Møller,Morten
松果体是一种神经内分泌腺，负责夜间合成褪黑激素。在早期发展的啮齿动物松果体从间脑的屋顶，同源盒基因的orthodenticle同源盒（OTx）和配对盒（Pax）家庭的表达和正常的松果体发育所必需的一致的既定的作用，同源盒基因在发育过程中发挥。然而，松果体似乎很不寻常，因为成人大脑的松果体中持续存在强烈的同源盒基因表达。因此，除了发育功能外，同源异型盒基因似乎是该组织中出生后表型维持的关键调节因子。本文综述了松果体发育的个体发生和系统发育方面的最新进展，了解在啮齿动物松果体发育和成人功能的homebox基因的参与。基于对大鼠发育和日常基因表达的详细分析、homebox基因缺陷小鼠的松果体表型以及对视网膜光感受器发育的研究，提出了一个理解同源盒基因在控制哺乳动物松果体细胞发育和成熟昼夜节律功能中的顺序作用的工作模型;松果体细胞和视网膜光感受器共享在其它组织中看不到的特征，并且可能是从相同的祖先光感受器细胞进化而来的。
The pineal gland is a neuroendocrine gland responsible for nocturnal synthesis of melatonin. During early development of the rodent pineal gland from the roof of the diencephalon, homeobox genes of the orthodenticle homeobox (Otx)- and paired box (Pax)-families are expressed and are essential for normal pineal development consistent with the well-established role that homeobox genes play in developmental processes. However, the pineal gland appears to be unusual because strong homeobox gene expression persists in the pineal gland of the adult brain. Accordingly, in addition to developmental functions, homeobox genes appear to be key regulators in postnatal phenotype maintenance in this tissue. In this paper, we review ontogenetic and phylogenetic aspects of pineal development and recent progress in understanding the involvement of homebox genes in rodent pineal development and adult function. A working model is proposed for understanding the sequential action of homeobox genes in controlling development and mature circadian function of the mammalian pinealocyte based on knowledge from detailed developmental and daily gene expression analyses in rats, the pineal phenotypes of homebox gene-deficient mice and studies on development of the retinal photoreceptor; the pinealocyte and retinal photoreceptor share features not seen in other tissues and are likely to have evolved from the same ancestral photodetector cell.