Angiogenic Microvascular Wall Shear Stress Patterns Revealed Through Three-dimensional Red Blood Cell Resolved Modeling.
Angiogenic Microvascular Wall Shear Stress Patterns Revealed Through Three-dimensional Red Blood Cell Resolved Modeling.
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DOI：
10.1093/function/zqad046
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发表时间：
2023
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影响因子：
--
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中科院分区：
文献类型：
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血液流经微血管所施加的壁切应力(WSS)是新血管生长或血管生成的既定驱动因素。这种适应在健康和疾病的许多生理过程中都是核心的，然而在真实的血管生成微血管网络中的三维(3D)WSS特征在很大程度上是未知的。这标志着一个重大的知识鸿沟，因为血管生成自然是一个3D过程。为了促进当前的理解，我们使用最先进的模拟技术对流经大鼠血管生成微血管网络的3D红细胞(RBC)进行了建模。高分辨率流体动力学揭示了发生在亚内皮细胞(EC)尺度上的3D WSS模式，这些模式源于不同的血管生成形态，包括微血管环和血管曲折。我们确定了由血管生成表面形状和红细胞引起的WSS热点和冷点的存在，并显著地增强了红细胞对WSS低区域的增强。时空特征进一步揭示了波动如何跟随RBC“足迹”的时间尺度。总之，这项工作为理解切应力如何调节体内EC的动力学提供了一个新的概念框架。
The wall shear stress (WSS) exerted by blood flowing through microvascular capillaries is an established driver of new blood vessel growth, or angiogenesis. Such adaptations are central to many physiological processes in both health and disease, yet three-dimensional (3D) WSS characteristics in real angiogenic microvascular networks are largely unknown. This marks a major knowledge gap because angiogenesis, naturally, is a 3D process. To advance current understanding, we model 3D red blood cells (RBCs) flowing through rat angiogenic microvascular networks using state-of-the-art simulation. The high-resolution fluid dynamics reveal 3D WSS patterns occurring at sub-endothelial cell (EC) scales that derive from distinct angiogenic morphologies, including microvascular loops and vessel tortuosity. We identify the existence of WSS hot and cold spots caused by angiogenic surface shapes and RBCs, and notably enhancement of low WSS regions by RBCs. Spatiotemporal characteristics further reveal how fluctuations follow timescales of RBC “footprints.” Altogether, this work provides a new conceptual framework for understanding how shear stress might regulate EC dynamics in vivo.
影响因子：
4.6
作者：
Moure A;Vilanova G;Gomez H
通讯作者：
Gomez H