Gene therapy for ovarian cancer.
Gene therapy for ovarian cancer.
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DOI：
10.1007/s11912-006-0073-x
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发表时间：
2006-11-01
影响因子：
4.7
通讯作者：
Alvarez, Ronald D
中科院分区：
文献类型：
--
作者：
Kimball, Kristopher J;Numnum, T Michael;Alvarez, Ronald D
卵巢癌仍然是美国女性妇科癌症死亡的主要原因。基于基因和病毒的疗法代表了癌症的新型治疗方法。为了达到治疗目的而操纵肿瘤细胞的遗传内容已分为几种一般策略，包括分子化疗、突变补偿、免疫增强和病毒疗法。递送载体以及基因转移和病毒复制评估的改进仍然是重要的研究领域。我们重点介绍了这些卵巢癌新治疗方法的最新进展，并总结了最近的临床试验。
Ovarian cancer remains the leading cause of death due to gynecologic cancer in women in the United States. Gene and viral-based therapies represent novel therapeutic approaches for cancer. The manipulation of genetic content of tumor cells toward a therapeutic end has been divided into several general strategies, including molecular chemotherapy, mutation compensation, immunopotentiation, and virotherapy. Improvements in delivery vehicles and in evaluation of gene transfer and viral replication remain important areas of investigation. We highlight the most recent advances in these novel therapeutic approaches for ovarian cancer and include a summary of recent clinical trials.