Increased selenoprotein P in choroid plexus and cerebrospinal fluid in Alzheimer's disease brain.
Increased selenoprotein P in choroid plexus and cerebrospinal fluid in Alzheimer's disease brain.
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DOI：
10.3233/jad-141755
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Bellinger FP
中科院分区：
文献类型：
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作者：
Rueli RH;Parubrub AC;Dewing AS;Hashimoto AC;Bellinger MT;Weeber EJ;Uyehara-Lock JH;White LR;Berry MJ;Bellinger FP
患有阿尔茨海默病（AD）的受试者具有升高的硒转运蛋白硒蛋白P（Sepp 1）的脑水平。我们研究了这种升高是否是由于脉络丛（CP）Sepp 1释放增加所致。与非AD脑相比，Sepp 1在AD脑的CP中显著增加。Sepp 1定位于CP上皮细胞内的trans-Golgi网络，在那里它被加工用于分泌。与非AD受试者相比，AD受试者的脑脊液中Sepp 1水平也有所增加。这些发现表明，AD病理诱导CP上皮细胞内Sepp 1水平增加，释放到脑脊液中，最终增加脑硒。
Subjects with Alzheimer’s disease (AD) have elevated brain levels of the selenium transporter selenoprotein P (Sepp1). We investigated if this elevation results from increased release of Sepp1 from the choroid plexus (CP). Sepp1 is significantly increased in CP from AD brains in comparison to non-AD brains. Sepp1 localizes to the trans-Golgi network within CP epithelia, where it is processed for secretion. The cerebrospinal fluid from AD subjects also contains increased levels Sepp1 in comparison to non-AD subjects. These findings suggest that AD pathology induces increased levels of Sepp1 within CP epithelia for release into the cerebrospinal fluid to ultimately increase brain selenium.