EFFECT OF INCREASED GASTRIC-MUCOSAL HISTAMINE ON ALCOHOL-INDUCED GASTRIC DAMAGE IN RATS
EFFECT OF INCREASED GASTRIC-MUCOSAL HISTAMINE ON ALCOHOL-INDUCED GASTRIC DAMAGE IN RATS
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DOI：
10.1007/bf01296755
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发表时间：
1982-01-01
影响因子：
3.1
通讯作者：
GROSSMAN, MI
中科院分区：
文献类型：
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作者：
AURES, D;GUTH, PH;GROSSMAN, MI
研究前列腺素的细胞保护作用是否可能通过抑制粘膜内组胺的释放来实现。在150 mM盐酸中灌胃增加乙醇浓度，可增加损伤评分和增加胃内容物中组胺的释放。16，16-二甲基前列腺素E_2可显著降低损伤评分和胃组胺排出量。组胺与示踪剂[14C]组胺与50%乙醇或50%乙醇一起灌胃后，胃组织对组胺的摄取显著增加，胃酸分泌增加。这对损伤评分、蛋白输出量和前列腺素预处理的保护作用没有影响。可见，16，16-二甲基前列腺素E_2对大鼠的细胞保护作用不依赖于粘膜内组胺的释放。
Whether the cytoprotective effect of prostaglandin might be mediated, by inhibition of intramucosal histamine release was studied. Intragastric instillation of increasing concentrations of ethanol in 150 mM HCl resulted in increasing lesion scores and increasing histamine release into the gastric content. Pretreatment with 16,16-dimethyl prostaglandin E2 significantly reduced lesion scores and gastric histamine output. The intragastric instillation of histamine with tracer [14C]histamine with or after 50% ethanol resulted in significant gastric tissue uptake of histamine and increased acid secretion. This had no effect on lesion score, protein output or the protective effect of prostaglandin pretreatment. Apparently, the cytoprotective effect of 16,16-dimethyl prostaglandin E2 in the rat was independent of intramucosal histamine release.