semang affects the development of a subset of cells in the Drosophila compound eye.
semang affects the development of a subset of cells in the Drosophila compound eye.
复制标题
semang 影响果蝇复眼中一部分细胞的发育。
DOI：
10.1016/s0925-4773(00)00340-3
复制
发表时间：
2000
影响因子：
2.6
通讯作者：
Lu,X
中科院分区：
文献类型：
--
作者：
Zhang,Q;Lu,X
semang（sag）是果蝇Src 42 A基因的一个抑制突变，以前已被证明影响某些受体酪氨酸激酶介导的胚胎过程。在这里，我们表明，下垂具体影响R1，R6和R7感光细胞的发展，在一个细胞自主的方式。这些细胞在突变体中不存在，而它们通常出现在小眼前簇中。遗传分析表明，下垂的功能下游，或平行于，Mapk和严在感光细胞分化途径。R1/R6/R7发展的自主要求可以解释为选择性损害的后期，但不是早期，轮Egfr诱导的前体细胞组装的sag突变。Egfr信号在不同细胞中受到自分泌或旁分泌机制的高度调节。我们知道光感受器簇的形成是一个复杂的过程，涉及细胞-细胞接触的动态变化，我们的假设是，sag等位基因影响某些特殊方面的EGFR信号，这是独特的招聘R1/R6/R7细胞。
semang (sag), a mutation isolated as a suppressor of Drosophila Src42A, has previously been shown to affect some receptor tyrosine kinase mediated embryonic processes. Here we show that sag specifically affects the development of R1, R6 and R7 photoreceptor cells in a cell-autonomous manner. These cells are absent in the mutant at the time when they normally appear in the ommatidial pre-clusters. Genetic analyses suggest that sag functions downstream of, or parallel to, Mapk and Yan in the photoreceptor differentiation pathway. The autonomous requirement of sag for R1/R6/R7 development could be explained by a selective impairment of the late, but not early, rounds of Egfr-induced precursor cell assembly by the sag mutations. Egfr signaling is highly regulated by autocrine or paracrine mechanisms in different cells. Knowing that the photoreceptor cluster formation is a complex process involving dynamic changes in cell–cell contact, our hypothesis is that the sag alleles affected certain special aspects of Egfr-signaling that are unique for the recruitment of R1/R6/R7 cells.