Genetic variance for autism screening items in an unselected sample of toddler-age twins.
Genetic variance for autism screening items in an unselected sample of toddler-age twins.
复制标题
未经选择的幼儿双胞胎样本中自闭症筛查项目的遗传方差。
DOI：
10.1016/j.jaac.2009.11.012
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发表时间：
2010
影响因子：
13.3
通讯作者：
Goldsmith,HillH
中科院分区：
文献类型：
--
作者：
Stilp,RebeccaLH;Gernsbacher,MortonAnn;Schweigert,EmilyK;Arneson,CarrieL;Goldsmith,HillH
对自闭症特征和自闭症诊断病例的双胞胎和家庭研究表明，自闭症特征的遗传性很高;然而，自闭症特征在幼儿中的遗传性还没有被研究过。因此，这项研究的目标是（1）筛选一个全州范围内的双胞胎人口使用的项目类似的六个关键的社会和沟通项目广泛用于自闭症筛查幼儿（自闭症幼儿的修订清单）;（2）评估这些项目在一般人群的认可率;（3），以确定其遗传率。对1,211对2至3岁双胞胎的母亲进行了筛查。通过一致率和四项和组内相关性计算双胞胎的相似性，并估计与单阈值有序models. CITTSThe人口为基础的双胞胎样本的六个关键项目的类似物上产生的背书率相似的规模的作者，他们用来确定一个自闭症阈值的贡献。目前的双胞胎相似性和模型拟合分析也使用这个阈值。单卵双胞胎（43%）和双卵双胞胎（20%）的病例一致率表明，在一般人群中，这些早期自闭症指标的遗传性中等。从模型拟合方差分量估计也建议中度遗传的分类scores.CONCLUSIONSAutism筛选分数是中度遗传的2- 3岁的双胞胎儿童从人口为基础的双胞胎面板。关于性别差异的推论受到了在幼儿年龄筛选器上得分高于阈值的女性的稀缺性的限制。
OBJECTIVETwin and family studies of autistic traits and of cases diagnosed with autism suggest high heritability; however, the heritability of autistic traits in toddlers has not been investigated. Therefore, this study's goals were (1) to screen a statewide twin population using items similar to the six critical social and communication items widely used for autism screening in toddlers (Modified Checklist for Autism in Toddlers); (2) to assess the endorsement rates of these items in a general population; and (3) to determine their heritability.METHODParticipants composed a statewide, unselected twin population. Screening items were administered to mothers of 1,211 pairs of twins between 2 and 3 years of age. Twin similarity was calculated via concordance rates and tetrachoric and intraclass correlations, and the contribution of genetic and environmental factors was estimated with single-threshold ordinal models.RESULTSThe population-based twin sample generated endorsement rates on the analogs of the six critical items similar to those reported by the scale's authors, which they used to determine an autism threshold. Current twin similarity and model-fitting analyses also used this threshold. Casewise concordance rates for monozygotic (43%) and dizygotic (20%) twins suggested moderate heritability of these early autism indicators in the general population. Variance component estimates from model-fitting also suggested moderate heritability of categorical scores.CONCLUSIONSAutism screener scores are moderately heritable in 2- to 3-year-old twin children from a population-based twin panel. Inferences about sex differences are limited by the scarcity of females who scored above the threshold on the toddler-age screener.