Exhaled Breath Marker in Asthma Patients with Gastroesophageal Reflux Disease
Exhaled Breath Marker in Asthma Patients with Gastroesophageal Reflux Disease
复制标题
哮喘合并胃食管反流病患者的呼出气标记物
DOI：
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发表时间：
2007
影响因子：
2.4
通讯作者：
M. Mori
中科院分区：
文献类型：
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作者：
Y. Shimizu;K. Dobashi;M. Mori
预防胃酸在胃食管反射病（GERD）相关哮喘治疗中非常重要。质子泵抑制剂（PPI）和H2受体阻滞剂已被报道为改善哮喘症状的有效疗法。GERD在哮喘中的患病率很高;然而，基于问卷调查、内镜检查和24小时pH监测来验证GERD存在的方法并不能直接确定GERD对气道的影响。呼出气冷凝物分析是一种新颖的和非侵入性的工具，用于评估信息直接从气道。通过冷却收集的呼吸可用于GERD相关哮喘患者的pH值、8-异前列烷和细胞因子分析，pH值和8-异前列烷水平已显示可反映PPI治疗对这些患者的影响。虽然冷呼吸的分析尚未在临床环境中建立，但该方法有望为监测GERD相关的气道酸化提供一种新的工具。
Prevention of acid is important in gastroesophageal reflex disease (GERD)-related asthma therapy. Proton pump inhibitors (PPI) and H2-receptor blockers have been reported as useful therapies for improving asthma symptoms. GERD prevalence is high in asthma; however, methods for validating GERD existence based on questionnaire, endoscopic examination and 24h-pH monitoring do not directly determine GERD influence on the airway. Exhaled breath condensate analysis is a novel and non-invasive tool for assessing information directly from the airway. Breath collected by cooling can be applied to pH, 8-isoprostane and cytokine analysis in patients with GERD-related asthma, and the pH and 8-isoprostane levels have been shown to reflect the effects of PPI therapy in these patients. Although the analysis of cooled breath has not yet been established in a clinical setting, this method is expected to provide a novel tool for monitoring airway acidification associated with GERD.