Plasma Catestatin in Patients with Acute Coronary Syndrome
Plasma Catestatin in Patients with Acute Coronary Syndrome
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急性冠状动脉综合征患者的血浆儿茶素
DOI：
10.1159/000448987
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发表时间：
2017-01-01
期刊：
影响因子：
1.9
通讯作者：
Gao, Wei
中科院分区：
文献类型：
--
作者：
Xu, Weixian;Yu, Haiyi;Gao, Wei
目的：测量急性冠状动脉综合征患者的血浆儿茶素水平，并研究儿茶素水平与长期结果之间是否存在关联。方法：纳入170例疑似急性冠状动脉综合征并接受急诊冠状动脉造影的患者，其中急性ST段抬高型心肌梗死（STEMI）46例，不稳定型心绞痛（UAP）89例，无冠状动脉疾病（CAD）35例。所有患者均接受为期 2 年的随访，以测量主要不良心血管事件 (MACE) 的发生情况，包括心血管原因死亡、复发性急性心肌梗死或因心力衰竭或血运重建入院。结果：平均而言，STEMI 患者 (0.80 ± 0.62 ng/ml) 和 UAP (0.99 ± 0.63 ng/ml) 患者血浆儿联蛋白水平显着低于无 CAD 证据的对照组 (1.38 ± 0.98 ng/ml；p = 0.001)。在多变量线性回归中，体重指数、高血压的存在和 CAD 类型与血浆儿联蛋白水平独立相关。然而，高和低水平儿茶素患者的 MACE 没有显着差异。结论：STEMI 和 UAP 患者的血浆儿联蛋白水平低于非 CAD 患者的水平。
Objectives: To measure plasma catestatin levels in patients with acute coronary syndrome and investigate whether there is an association between catestatin levels and long-term outcome. Methods: Patients (n = 170) with suspected acute coronary syndrome who underwent emergency coronary angiography were enrolled, including 46 with acute ST-segment elevation myocardial infarction (STEMI), 89 with unstable angina pectoris (UAP), and 35 without coronary artery disease (CAD). All patients were followed for 2 years to measure the occurrence of major adverse cardiovascular events (MACEs), including death from a cardiovascular cause, recurrent acute myocardial infarction, or hospital admission for heart failure or revascularization. Results: On average, the plasma catestatin levels in patients with STEMI (0.80 ± 0.62 ng/ml) and UAP (0.99 ± 0.63 ng/ml) were significantly lower than the levels seen in the control group with no evidence of CAD (1.38 ± 0.98 ng/ml; p = 0.001). In multivariable linear regression, body mass index, presence of hypertension, and type of CAD were independently related to the plasma catestatin level. However, there were no significant differences in MACEs between patients with high and low levels of catestatin. Conclusions: The plasma catestatin levels in patients with STEMI and UAP were lower than the levels seen in patients without CAD.