Enhanced Negative Regulation of the DHH Signaling Pathway as a Potential Mechanism of Ascrotal Testes in Laurasiatherians
Enhanced Negative Regulation of the DHH Signaling Pathway as a Potential Mechanism of Ascrotal Testes in Laurasiatherians
复制标题
DHH 信号通路的增强负调节作为劳亚兽类腹囊睾丸的潜在机制
DOI：
10.1007/s11692-021-09542-0
复制
发表时间：
2021-05-28
影响因子：
2.5
通讯作者：
Ren, Wenhua
中科院分区：
文献类型：
--
作者：
Chai, Simin;Tian, Ran;Ren, Wenhua
人类和其他阴囊哺乳动物睾丸下降不成功会导致隐睾，随之而来的畸形和恶性肿瘤的高风险。然而，许多具有天然阴囊睾丸的雄性成年哺乳动物与其他阴囊哺乳动物一样健康。本研究主要在laurasiatherians中对睾丸发育的重要调节因子--沙漠刺猬（DHH）信号通路进行了进化分析。显著的正选择，加速进化速率，和特定的氨基酸取代被确定在ascrotal物种，其中一些引起根本性的变化，在理化和生物学特性。考虑到大多数正选择的迹象被确定在基因负责或相关的负调控，我们认为，DHH信号通路的增强负调控驱动器，至少部分，ascrotal睾丸在laurasiatherians和其他哺乳动物的进化。这项研究可以提供一些新的见解自然健康的哺乳动物隐睾的进化和复杂性状的趋同分子进化。
Unsuccessful descent of testes in humans and other scrotal mammals can result in cryptorchidism, consequent abnormalities and a high risk of malignancy. However, many male adult mammals possessing natural ascrotal testes are as viable and healthy as other scrotal mammals. This study performed an evolutionary analysis on the desert hedgehog (DHH) signaling pathway, an important regulator for testicular development, mainly in laurasiatherians. Significant positive selection, accelerated evolutionary rates, and specific amino acid substitutions were identified in ascrotal species, some of which caused radical changes in physicochemical and biological properties. Considering that most signs of positive selection were identified in genes responsible for or related to negative regulation, we suggest that the enhanced negative regulation of the DHH signaling pathway drives, at least in part, the evolution of ascrotal testes in laurasiatherians and other mammals. This study could provide some novel insights into the evolution of natural healthy ‘cryptorchidism’ in mammals and into the convergent molecular evolution of the complex trait.