Taste receptors in the gastrointestinal tract.: I.: Bitter taste receptors and α-gustducin in the mammalian gut
Taste receptors in the gastrointestinal tract.: I.: Bitter taste receptors and α-gustducin in the mammalian gut
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DOI：
10.1152/ajpgi.00073.2006
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发表时间：
2006-08-01
影响因子：
4.5
通讯作者：
Rozengurt, Enrique
中科院分区：
文献类型：
--
作者：
Rozengurt, Enrique
胃肠（GI）细胞的分子传感在控制消化中的多种基本功能中起着关键作用，并且还启动激素和/或神经通路，从而调节热量摄入、胰腺胰岛素分泌和代谢。胃肠道中的分子传感还负责检测摄入的有害药物和毒素，从而启动对生存至关重要的反应。最初的识别事件和所涉及的机制仍然不完全清楚。在这篇文章中要讨论的概念是，有重要的相似之处之间的chemosensory机械阐明专门的神经上皮味觉受体细胞的舌上皮和分子换能器定位最近在肠内分泌开放GI细胞的感觉的化学成分的管腔内容物的肠道。
Molecular sensing by gastrointestinal (GI) cells plays a critical role in the control of multiple fundamental functions in digestion and also initiates hormonal and/or neural pathways leading to the regulation of caloric intake, pancreatic insulin secretion, and metabolism. Molecular sensing in the GI tract is also responsible for the detection of ingested harmful drugs and toxins, thereby initiating responses critical for survival. The initial recognition events and mechanism(s) involved remain incompletely understood. The notion to be discussed in this article is that there are important similarities between the chemosensensory machinery elucidated in specialized neuroepithelial taste receptor cells of the lingual epithelium and the molecular transducers localized recently in enteroendocrine open GI cells that sense the chemical composition of the luminal contents of the gut.