Elastase in tissue injury.
Elastase in tissue injury.
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DOI：
10.1146/annurev.me.36.020185.001231
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发表时间：
1985
影响因子：
10.5
通讯作者：
A. Janoff
中科院分区：
文献类型：
--
作者：
A. Janoff
本文综述了人体中的弹性蛋白酶，不包括胰腺和消化道的酶。特别强调的是多形核中性粒细胞（PMN）的弹性蛋白酶。后一种酶的性质，其在血浆和结缔组织中的靶分子，及其内源性调节剂进行了简要讨论。酶的持久活性，即使在其监管抑制剂的存在下，解释。本章最后简要讨论了几种肺部疾病，其中弹性蛋白酶介导的组织损伤被认为发挥了作用。
This article surveys elastinolytic proteinases in man, excluding enzymes of the pancreas and digestive tract. Special emphasis is placed on the elastase of polymorphonuclear neutrophils (PMN). The properties of this latter enzyme, its target molecules in plasma and connective tissues, and its endogenous regulators are briefly discussed. Persistent activity of the enzyme, even in the presence of its regulatory inhibitors, is explained. The chapter closes with a brief discussion of several pulmonary diseases in which elastase-mediated tissue injury is thought to play a role.