No Effect of Anodal Transcranial Direct Current Stimulation Over the Motor Cortex on Response-Related ERPs during a Conflict Task.
No Effect of Anodal Transcranial Direct Current Stimulation Over the Motor Cortex on Response-Related ERPs during a Conflict Task.
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在冲突任务中，阳极经颅直流电流刺激对与响应相关的ERP没有影响。
DOI：
10.3389/fnhum.2016.00384
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发表时间：
2016
影响因子：
2.9
通讯作者：
Karayanidis F
中科院分区：
文献类型：
--
作者：
Conley AC;Fulham WR;Marquez JL;Parsons MW;Karayanidis F
运动皮层的阳极经颅直流电刺激（tDCS）被认为是中风和其他神经病理性疾病后运动康复的潜在治疗方法。然而，这种刺激有效的背景和潜在机制仍有待确定。在本研究中，我们通过在年轻人的主导初级运动皮层 (M1) 和老年人的主导和非主导 M1（实验 2）上进行阳极 tDCS 后，在提示 go/nogo 任务期间记录事件相关电位 (ERP)，研究了阳极 tDCS 可能影响运动表现的机制。在这两个实验中，阳极 tDCS 对响应时间 (RT) 或响应相关的 ERP 没有影响，包括提示锁定的偶然负变化 (CNV) 以及目标锁定和响应锁定的侧化准备电位 (LRP)。贝叶斯模型选择分析表明，对于所有测量，零效应模型均强于包含阳极 tDCS 的模型与假手术的模型。我们得出的结论是，无论是年轻人还是老年人，在提示进行/不进行任务期间，阳极 tDCS 对 RT 或反应相关的 ERP 没有影响。
Anodal transcranial direct current stimulation (tDCS) over the motor cortex is considered a potential treatment for motor rehabilitation following stroke and other neurological pathologies. However, both the context under which this stimulation is effective and the underlying mechanisms remain to be determined. In this study, we examined the mechanisms by which anodal tDCS may affect motor performance by recording event-related potentials (ERPs) during a cued go/nogo task after anodal tDCS over dominant primary motor cortex (M1) in young adults (Experiment 1) and both dominant and non-dominant M1 in older adults (Experiment 2). In both experiments, anodal tDCS had no effect on either response time (RT) or response-related ERPs, including the cue-locked contingent negative variation (CNV) and both target-locked and response-locked lateralized readiness potentials (LRP). Bayesian model selection analyses showed that, for all measures, the null effects model was stronger than a model including anodal tDCS vs. sham. We conclude that anodal tDCS has no effect on RT or response-related ERPs during a cued go/nogo task in either young or older adults.