ENTH/ANTH domains expand to the Golgi
ENTH/ANTH domains expand to the Golgi
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DOI：
10.1016/s0962-8924(03)00076-x
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发表时间：
2003-05-01
影响因子：
19
通讯作者：
Payne, GS
中科院分区：
文献类型：
--
作者：
Duncan, MC;Payne, GS
网格蛋白包被囊泡（CCV）在营养摄取、信号受体下调、病原体入侵以及内体和溶酶体的生物合成中起重要作用。虽然已经出现了内吞CCV形成的详细模型，但在高尔基体和内体形成CCV的过程还不太清楚。内吞CCV形成的关键是含有相关磷酸肌醇结合ENTH和ANTH结构域的蛋白质。现在，最近的研究已经确定了新的ENTH/ANTH蛋白，参与CCV介导的trans-Golgi网络（TGN）和内体之间的交通，并确定了与AP-1和GGA衔接子在网格蛋白外套的TGN/内体的相互作用的分子基础。因此，ENTH/ANTH结构域蛋白似乎是网格蛋白外壳成核的通用元素。
Clathrin-coated vesicles (CCVs) play important roles in nutrient uptake, downregulation of signaling receptors, pathogen invasion and biogenesis of endosomes and lysosomes. Although detailed models for endocytic CCV formation have emerged, the, process of CCV formation at the Golgi and endosomes has been less clear. Key to endocytic CCV formation are proteins containing related phosphoinositide-binding ENTH and ANTH domains. Now, recent studies have identified novel ENTH/ANTH proteins that participate in CCV-mediated traffic between the trans-Golgi Network (TGN) and endosomes and have defined a molecular basis for interaction with AP-1 and GGA adaptors in clathrin coats of the TGN/endosomes. Thus, ENTH/ANTH domain proteins appear to be universal elements in nucleation of clathrin coats.