Hemorrhagic fever with renal syndrome in Korea.
Hemorrhagic fever with renal syndrome in Korea.
复制标题
韩国肾综合征出血热。
DOI：
10.1093/clinids/11.supplement_4.s864
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
H. Lee
中科院分区：
文献类型：
--
作者：
H. Lee
肾综合征出血热(HFRS)的几种临床变种是由汉滩及相关病毒引起的。自1951年以来，韩国每年有500-900名肾综合征出血热患者住院治疗。尽管肾综合征出血热主要与农村地区有关，但它现在被认为是一个城市问题，对使用啮齿动物进行研究的实验室工作人员来说是一个特别的危险。最近，在肾综合征出血热季节发生了钩端螺旋体病和斑疹伤寒的流行，导致诊断混乱。肾综合征出血热的血清学诊断是基于间接荧光抗体技术或酶联免疫吸附试验证实汉坦病毒的IgM抗体。根据空斑减少中和抗体的滴度可以识别引起感染的特定汉坦病毒。对单抗的研究结果表明，目前公认的每一种汉坦病毒血清型都存在病毒亚型。虽然感染汉坦病毒已知是一个世界性的问题，但目前的证据表明，它发生在比以前认识到的更广泛的区域。汉滩病毒在孕妇中的垂直传播已被记录在案。
Several clinical variants of hemorrhagic fever with renal syndrome (HFRS) are caused by Hantaan and related viruses. Since 1951, 500-900 patients with HFRS have been hospitalized annually in Korea. Although HFRS is associated primarily with rural areas, it is now being recognized as an urban problem and a particular hazard to laboratory staff using rodents for research. Recently, epidemic outbreaks of leptospirosis and scrub typhus have occurred during the HFRS season, leading to confusion in diagnosis. Serologic diagnosis of HFRS is based on the demonstration of IgM antibodies to Hantaviruses by the indirect fluorescent antibody technique or enzyme-linked immunosorbent assay. The specific Hantavirus causing infection can be identified on the basis of titers of plaque-reduction neutralizing antibody. Results of studies with monoclonal antibodies suggest that viral subtypes exist for each Hantaviral serotype presently recognized. While infection with Hantaviruses is known to be a problem of worldwide dimensions, present evidence indicates that it occurs over a wider area than previously recognized. Vertical transmission of Hantaan virus in a pregnant woman has been documented.