Redundancy: a critical obstacle to improving cancer therapy.
Redundancy: a critical obstacle to improving cancer therapy.
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DOI：
10.1158/0008-5472.can-14-3256
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发表时间：
2015-03-01
期刊：
影响因子：
11.2
通讯作者：
Lavi O
中科院分区：
文献类型：
--
作者：
Lavi O
一个以冗余为特征的系统具有能够以相同的生物或动态方式起作用的各种元素，其中抑制这些元素之一对全局生物结果或系统的动态行为没有显著影响。旨在预测癌症治疗有效性的方法必须包括进化和动态特征，这些特征将改变被广泛接受的静态观点。在这里，我们探讨了冗余，异质性，生物学重要性和耐药性的机制的几个重要问题，并描述了方法上的挑战，如果克服，将显着有助于癌症研究。
A system characterized by redundancy has various elements that are able to act in the same biological or dynamic manner, where the inhibition of one of those elements has no significant effect on the global biological outcome or on the system’s dynamic behavior. Methods that aim to predict the effectiveness of cancer therapies must include evolutionary and dynamic features that would change the static view that is widely accepted. Here, we explore several important issues about mechanisms of redundancy, heterogeneity, biological importance and drug resistance and describe methodological challenges that, if overcome, would significantly contribute to cancer research.