Spectral Imaging Of Thermal Damage Induced During Microwave Ablation In The Liver.
Spectral Imaging Of Thermal Damage Induced During Microwave Ablation In The Liver.
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肝脏微波消融过程中引起的热损伤的光谱成像。
DOI：
10.1109/embc.2018.8512901
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Clancy NT
中科院分区：
文献类型：
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作者：
Clancy NT
通过传递微波能量来诱导对组织的热损伤在外科手术中经常被用来摧毁诸如癌细胞之类的病变组织。最大限度地减少对健康组织的有害伤害仍然是主观上实现的，外科医生几乎没有可用的工具来监控诱导损伤的传播。这项工作描述了使用光学方法来监测在猪肝脏中传递微波能量期间组织变化的时间进程。多光谱成像和漫反射光谱被用来监测光学性质的时间变化，与热成像并行。结果表明，能够监测整个器官的热损伤的空间范围，包括可能由于血管损伤而产生的次要影响。这种类型的成像的未来应用可能会看到多光谱数据被用作反馈机制，以避免对关键的健康结构的附带损害，并潜在地验证对患病组织的足够能量应用。
Induction of thermal damage to tissue through delivery of microwave energy is frequently applied in surgery to destroy diseased tissue such as cancer cells. Minimization of unwanted harm to healthy tissue is still achieved subjectively, and the surgeon has few tools at their disposal to monitor the spread of the induced damage. This work describes the use of optical methods to monitor the time course of changes to the tissue during delivery of microwave energy in the porcine liver. Multispectral imaging and diffuse reflectance spectroscopy are used to monitor temporal changes in optical properties in parallel with thermal imaging. The results demonstrate the ability to monitor the spatial extent of thermal damage on a whole organ, including possible secondary effects due to vascular damage. Future applications of this type of imaging may see the multispectral data used as a feedback mechanism to avoid collateral damage to critical healthy structures and to potentially verify sufficient application of energy to the diseased tissue.