Podocyte-specific Transcription Factors: Could MafB Become a Therapeutic Target for Kidney Disease?
Podocyte-specific Transcription Factors: Could MafB Become a Therapeutic Target for Kidney Disease?
复制标题
足细胞特异性转录因子：MAFB可以成为肾脏疾病的治疗靶点吗？
DOI：
10.2169/internalmedicine.9336-22
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发表时间：
2023-01-01
影响因子：
1.2
通讯作者：
Yamagata, Kunihiro
中科院分区：
文献类型：
--
作者：
Morito, Naoki;Usui, Toshiaki;Ishibashi, Shun;Yamagata, Kunihiro
越来越多的慢性肾脏疾病（CKD）患者被认为是一个新兴的全球健康问题。最近，肾小球内脏上皮细胞（即足细胞）的损伤和丢失在许多形式的CKD中是一个常见的早期事件。足细胞是高度特化的上皮细胞，覆盖在肾小球基底膜的外层。它们通过形成和维持专门的足突和中间的裂口隔膜，作为尿蛋白损失的最后屏障。我们之前报道过转录因子MafB调控足细胞狭缝膜蛋白的产生和转录因子Tcf21。我们发现强迫表达MafB能够预防CKD。在这篇综述中，我们讨论了最近的进展，并提供了足细胞特异性转录因子在肾脏生物学中的功能的最新概述，旨在为CKD的进展和相应的治疗策略提供新的视角。
The increasing number of patients with chronic kidney disease (CKD) is being recognized as an emerging global health problem. Recently, it has become clear that injury and loss of glomerular visceral epithelial cells, known as podocytes, is a common early event in many forms of CKD. Podocytes are highly specialized epithelial cells that cover the outer layer of the glomerular basement membrane. They serve as the final barrier to urinary protein loss through the formation and maintenance of specialized foot-processes and an interposed slit-diaphragm. We previously reported that the transcription factor MafB regulates the podocyte slit diaphragm protein production and transcription factor Tcf21. We showed that the forced expression of MafB was able to prevent CKD. In this review, we discuss recent advances and offer an updated overview of the functions of podocyte-specific transcription factors in kidney biology, aiming to present new perspectives on the progression of CKD and respective therapeutic strategies.
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