PREVALENCE OF MENOPAUSAL SYMPTOMS AMONG WOMEN WITH A HISTORY OF BREAST-CANCER AND ATTITUDES TOWARD ESTROGEN REPLACEMENT THERAPY
PREVALENCE OF MENOPAUSAL SYMPTOMS AMONG WOMEN WITH A HISTORY OF BREAST-CANCER AND ATTITUDES TOWARD ESTROGEN REPLACEMENT THERAPY
复制标题
DOI：
10.1200/jco.1995.13.11.2737
复制
发表时间：
1995-11-01
影响因子：
45.3
通讯作者：
FETTING, JH
中科院分区：
文献类型：
--
作者：
COUZI, RJ;HELZLSOUER, KJ;FETTING, JH
目的：了解乳腺癌患者血管舒缩、妇科等症状的患病率、严重程度、对雌激素替代治疗(ERT)的信念以及在医学监督下服用雌激素的意愿。材料和方法：对1988~1992年间确诊为原位或浸润性局部乳腺癌的320名40~65岁女性进行问卷调查。绝经后妇女的症状发生率如下：潮热，65%；盗汗，44%；阴道干燥，48%；性交困难，26%；睡眠困难，44%；以及感到抑郁，44%。后两种症状的出现频率随着血管舒缩症状严重程度的增加而增加(P<0.001)。41%的更年期女性认为，自从她们被诊断患有乳腺癌以来，她们经历了与更年期有关的身体或情感问题。在这些女性中，50%的人认为她们需要治疗。总体而言，31%的绝经后女性会考虑服用雌激素。那些认为他们的牛群经历了更年期问题的人比那些没有经历更年期问题的人更有可能考虑雌激素(42%比22%，P=0.003)。愿意服用雌激素的比例随着症状的严重程度的增加而增加，特别是抑郁和睡眠障碍的感觉(趋势分别为0.008和0.007)。人们意识到雌激素会降低心脏病和骨质疏松症的风险，但这与服用雌激素的意愿增加并不相关。然而，相信雌激素会增加复发乳腺癌和子宫癌的风险与降低服用雌激素的意愿有关(分别为P=0.003和0.08)。结论：血管舒缩症状对乳腺癌患者的生活质量有显著影响。临床试验以确定最安全和最有效的方法来缓解这些症状是必要的。(C)美国临床肿瘤学会1995年。
Purpose: To determine the prevalence and severity of vasomotor, gynecologic, and other symptoms among breast cancer patients, their health concerns, beliefs about estrogen replacement therapy (ERT), and willingness to take estrogen under medical supervision.Materials and Methods: A questionnaire was mailed to 320 women aged 40 to 65 years and diagnosed with in situ or invasive locoregional breast cancer in the years 1988 to 1992.Results: Of 222 eligible respondents, 190 were post menopausal. The prevalence of symptoms among the postmenopausal women was as follows: hot flashes, 65%; night sweats, 44%; vaginal dryness, 48%; dyspareunia, 26%; difficulty sleeping, 44%; and feeling depressed, 44%. The latter two symptoms increased in frequency with increasing severity of vasomotor symptoms (P for trend less than or equal to .001). Forty-one percent of menopausal women perceived that they had experienced, since their breast cancer diagnosis, a physical or emotional problem related to menopause. Of these women, 50% felt they needed treatment. Overall, 31% of postmenopausal women would consider taking estrogen. Those who perceived that they herd experienced a menopausal problem were more likely to consider estrogen than those who did not (42% v 22%, P = .003). The proportions willing to take estrogen increased with increasing severity of symptoms, particularly feelings of depression and sleep disturbance (P for trend = .008 and .007, respectively). Awareness that estrogen decreases the risks of heart disease and osteoporosis was not associated with an increased willingness to take it. However, beliefs that estrogen increases the risks of recurrent breast cancer and uterine cancer were associated with a decreased willing ness to take it (P = .003 and .08, respectively).Conclusion: Vasomotor symptoms have a significant impact on the quality af life of breast cancer patients. Clinical trials ta determine the safest and most effective ways ta relieve these symptoms are needed.(C) 1995 by American Society of Clinical Oncology.