Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production
Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production
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DOI：
10.1016/s0140-6736(03)12564-0
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发表时间：
2003-02-22
期刊：
影响因子：
168.9
通讯作者：
Granger, DL
中科院分区：
文献类型：
--
作者：
Lopansri, BK;Anstey, NM;Granger, DL
一氧化氮（NO）的生产和单核细胞NO合酶2（NOS 2）的表达在健康的坦桑尼亚儿童中很高，但在那些脑型疟疾低。下调NOS 2的因子也减少了参与细胞摄取和L-精氨酸生物合成的因子，L-精氨酸是NO合成的底物。因此，我们推测，L-精氨酸浓度将是低的个人与脑型疟疾。我们测量了坦桑尼亚患有和没有疟疾的儿童的冷冻保存血浆样本中L-精氨酸的浓度。脑型疟疾患者的L-精氨酸浓度较低（平均46 mumol/L，SD 14），无并发症疟疾患者的L-精氨酸浓度居中（70 mumol/L，20），健康对照组的L-精氨酸浓度在正常范围内（122 mumol/L，22; p
Nitric oxide (NO) production and mononuclear cell NO synthase 2 (NOS2) expression are high in healthy Tanzanian children but low in those with cerebral malaria. Factors that downregulate NOS2 also diminish factors involved in cellular uptake and biosynthesis of L-arginine, the substrate for NO synthesis. We therefore postulated that L-arginine concentrations would be low in individuals with cerebral malaria. We measured concentrations of L-arginine in cryopreserved plasma samples from Tanzanian children with and without malaria. L-arginine concentrations were low in individuals with cerebral malaria (mean 46 mumol/L, SD 14), intermediate in those with uncomplicated malaria (70 mumol/L, 20), and within the normal range in healthy controls (122 mumol/L, 22; p