A computational model of oxytocin modulation of olfactory recognition memory
A computational model of oxytocin modulation of olfactory recognition memory
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DOI：
10.1523/eneuro.0201-19.2019
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发表时间：
2019-07-01
期刊：
影响因子：
3.4
通讯作者：
Kelsch, Wolfgang
中科院分区：
文献类型：
--
作者：
Linster, Christiane;Kelsch, Wolfgang
哺乳动物的社会识别取决于感觉和其他大脑区域之间的复杂相互作用以及特定神经肽（例如催产素（OXT））的调节输入。社会识别记忆已被证明特别依赖于嗅觉处理，并且可以使用类似于探测非社会气味记忆时使用的方法来探测。我们在这里使用小鼠中两个相互连接的嗅觉网络（嗅球和前嗅核）的计算模型，提出一种嗅觉短期识别记忆及其在社交情境中的调节机制。根据之前的实验，我们提出一个早期的记忆轨迹是嗅球。在小鼠的社交接触过程中，AON 中的锥体细胞本身由嗅觉输入驱动，通过 OXT 的释放而变得更加兴奋，从而对嗅球局部中间神经元产生更强的反馈。 OB 的这种额外输入会产生更强的动态并提高 OB 中气味响应的信噪比。因此，小鼠的社会嗅觉记忆被更强烈地编码，并且它们的持续时间受到调节。
Social recognition in mammals depends on complex interactions between sensory and other brain areas as well as modulatory inputs by specific neuropeptides such as oxytocin (OXT). Social recognition memory specifically has been shown to depend among others on olfactory processing, and can be probed using methods similar to those used when probing non-social odor memory. We here use a computational model of two interconnected olfactory networks in the mouse, the olfactory bulb and anterior olfactory nucleus, to propose a mechanism for olfactory short term recognition memory and its modulation in social situations. Based on previous experiments, we propose one early locus for memory to be the olfactory bulb. During social encounters in mice, pyramidal cells in the AON, themselves driven by olfactory input, are rendered more excitable by OXT release, resulting in stronger feedback to olfactory bulb local interneurons. This additional input to the OB creates stronger dynamics and improves signal to noise ratio of odor responses in the OB proper. As a consequence, mouse social olfactory memories are more strongly encoded and their duration is modulated.