Brain 5beta-reductase: a correlate of behavioral sensitivity to androgen.
Brain 5beta-reductase: a correlate of behavioral sensitivity to androgen.
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脑 5β-还原酶：与雄激素行为敏感性的相关性。
DOI：
10.1126/science.7244635
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发表时间：
1981
期刊：
影响因子：
56.9
通讯作者：
T. Steimer
中科院分区：
文献类型：
--
作者：
J. Hutchison;T. Steimer
睾酮在鸽子的大脑中被转化为5种β -减少的代谢物，这些代谢物不会影响行为。长期阉割的鸟类对睾酮的行为影响相对不敏感，视前5 β -还原酶的活性增加。这种增加是特定于视前区域的，可以被雌激素逆转。通过5 - β还原使睾酮失活可能与控制大脑对雄激素的敏感性有关。
Testosterone is converted in the dove (Streptopelia risoria) brain to 5 beta-reduced metabolites that do not affect behavior. In long-term castrated birds, which are relatively insensitive to the behavioral effects of testosterone, the activity of preoptic 5 beta-reductase is increased. The increase, which is specific to the preoptic area, is reversed by estrogen. Inactivation of testosterone by 5 beta-reduction may be involved in the control of brain sensitivity to androgen.