Synthesis and application of chiral phosphino-imidazoline ligands: Ir-catalyzed enantioselective hydrogenation.
Synthesis and application of chiral phosphino-imidazoline ligands: Ir-catalyzed enantioselective hydrogenation.
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DOI：
10.1002/chin.200318026
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发表时间：
2002-12
期刊：
影响因子：
5.2
通讯作者：
Frederik Menges;M. Neuburger;A. Pfaltz
中科院分区：
文献类型：
--
作者：
Frederik Menges;M. Neuburger;A. Pfaltz
[反应：见正文]合成了一系列具有不同取代基的手性膦-咪唑配体(PHIM配体)1a-j，它们的立体生成中心、咪唑啉环上的氮原子和磷原子上具有不同的取代基。由这些配体衍生的Ir络合物已被评价为非官能化烯烃的对映选择性氢化催化剂。在一些情况下，观察到比类似的膦-恶唑啉配体更高的对映体过量。
[reaction: see text] A series of chiral phosphino-imidazolines (PHIM ligands) 1a-j with different substituents at the stereogenic center, the nitrogen atom of the imidazoline ring, and at the phosphorus atom were synthesized. Iridium complexes derived from these ligands have been evaluated as catalysts for the enantioselective hydrogenation of unfunctionalized olefins. In several cases, higher enantiomeric excesses were observed than with analogous phosphino-oxazoline ligands.