Targeted endoscopic imaging.
Targeted endoscopic imaging.
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DOI：
10.1016/j.giec.2009.02.001
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发表时间：
2009-04
影响因子：
--
通讯作者：
Wang, Thomas D
中科院分区：
文献类型：
--
作者：
Li, Meng;Wang, Thomas D
近年来，内窥镜技术经历了爆炸性的发展，随着靶向成像的出现，其真正的变革力量和对医学的影响即将显现。如今，我们通过医学内窥镜观察消化道内部的能力正走向令人兴奋的十字路口。基于观察结构变化和识别解剖标志来做出诊断决策的现有范例可能很快就会被可视化功能特性和成像分子表达所取代。在这种新方法中，识别了疾病特有的细胞内和细胞表面靶点的存在，并用于预测粘膜转化和对治疗的反应的可能性。这一策略可以促进早期癌症检测、个性化治疗和化学预防新方法的开发。这种有针对性的方法需要进一步开发分子探针和内窥镜仪器，并且需要 FDA 的支持以简化监管。总体而言，这种分子成像方式有望通过提供一种以前所未有的方式可视化消化道粘膜的新方法来显着拓宽胃肠病学家的能力。
Endoscopy has undergone explosive technological growth in over recent years, and with the emergence of targeted imaging, its truly transformative power and impact in medicine lies just over the horizon. Today, our ability to see inside the digestive tract with medical endoscopy is headed toward exciting crossroads. The existing paradigm of making diagnostic decisions based on observing structural changes and identifying anatomical landmarks may soon be replaced by visualizing functional properties and imaging molecular expression. In this novel approach, the presence of intracellular and cell surface targets unique to disease are identified and used to predict the likelihood of mucosal transformation and response to therapy. This strategy can result in the development of new methods for early cancer detection, personalized therapy, and chemoprevention. This targeted approach will require further development of molecular probes and endoscopic instruments, and will need support from the FDA for streamlined regulatory oversight. Overall, this molecular imaging modality promises to significantly broaden the capabilities of the gastroenterologist by providing a new approach to visualize the mucosa of the digestive tract in a manner that has never been seen before.