ELASTICITY OF CANINE AND HUMAN CORONARY-ARTERIES WITH REFERENCE TO POSTMORTEM CHANGES
ELASTICITY OF CANINE AND HUMAN CORONARY-ARTERIES WITH REFERENCE TO POSTMORTEM CHANGES
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DOI：
10.1161/01.res.45.5.588
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发表时间：
1979-01-01
影响因子：
20.1
通讯作者：
HADFIELD, CD
中科院分区：
文献类型：
--
作者：
GOW, BS;HADFIELD, CD
冠状动脉的弹性特性是冠心病发生的重要力学因素。鉴于人体动脉研究需要尸体标本，本文对一条肌性动脉（股动脉）经切除、冷藏后的弹性变化进行了初步研究。动态（Edyn）和静态（Estat）增量，所有动脉的弹性模量计算从同时记录的压力和直径的痕迹，后者，在大多数情况下，获得与现有的电动卡尺。一种新的，重量轻，应变卡尺的发展，使直接直径记录从左回旋冠状动脉（LCCA）的跳动犬心脏。在切除和冷藏过夜后，犬股动脉分别显示直径增加（9.2%和11.6%）、Estat增加（77%和173%）和Edyn增加（46%和99%）。这些变化可能适用于冠状动脉，因为它们的中间结构相似。犬LCCA的Edyn为1.23 ±。0.12 N·m-2 ×106，与已发表的股动脉和颈动脉数据非常一致。6个切除的人冠状动脉（年龄14-40岁的受试者）的Estat和Edyn的平均值和SEM [平均值的标准误差]值为2.31 ± 0.01。0.49和4.46 .+-。1.21（SEM）N·cm-2 ×106;与上述体内数据相比，这些值更高，但与其他切除的人体血管的已发表值一致。死后弹性的增加表明人类冠状动脉和股动脉可能具有相似的弹性特性，即，Edyn = 1.2 N·m-2 ×106.
The elastic properties of coronary arteries are essential mechanical factors in coronary heart disease. In view of the necessity of using postmortem material to study human arteries, a preliminary study was made on the elasticity changes of a muscular artery (the femoral) after excision and cold storage. Dynamic (Edyn) and static (Estat) incremental, elastic moduli of all arteries were calculated from simultaneously recorded pressure and diameter traces, the latter, in most instances, being obtained with an existing electrical caliper. A new, light-weight, strain-gauge caliper was developed to allow direct diameter records to be obtained from the left circumflex coronary artery (LCCA) on the beating canine heart. After excision and overnight cold storage, respectively, the canine femoral artery showed increases in diameter (9.2 and 11.6%), Estat (77 and 173%), and Edyn (46 and 99%). These changes are probably applicable to the coronary arteries in view of the similarities in their medial structure. Edyn for the canine LCCA was 1.23 .+-. 0.12 N.cntdot.m-2 .times. 106 and was in excellent agreement with published data for femoral and carotid arteries. The mean and SEM [standard error of the mean] values of Estat and Edyn for 6 excised, human coronary arteries (subjects 14-40 yr of age) were 2.31 .+-. 0.49 and 4.46 .+-. 1.21 (SEM) N.cntdot.m-2 .times. 106, respectively; these are higher in comparison to the above in vivo data but agree with published values from other excised human vessels. The postmortem increases in elasticity indicate that human coronary and femoral arteries probably have similar elastic properties, i.e., Edyn = 1.2 N.cntdot.m-2 .times. 106.