Association of body mass index with morbidity in patients hospitalised with COVID-19.
Association of body mass index with morbidity in patients hospitalised with COVID-19.
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DOI：
10.1136/bmjresp-2021-000970
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发表时间：
2021-08
影响因子：
4.1
通讯作者：
Schenck EJ
中科院分区：
文献类型：
--
作者：
Plataki M;Pan D;Goyal P;Hoffman K;Choi JMK;Huang H;Safford MM;Schenck EJ
评估因COVID-19住院并插管的患者的体重指数（BMI）与除死亡外的临床结局之间的相关性。这是一项针对2020年3月3日至2020年5月15日期间在纽约长老会医院-威尔康奈尔医学中心住院的COVID-19成年患者的单中心队列研究。按BMI分类分层后，生成入院和插管队列的基线和结局变量以及实验室和诊断参数。线性回归模型用于连续性结局，逻辑回归模型用于分类结局。该研究包括1337例住院患者，其中407例插管患者。在住院患者中，住院时间（LOS）和出院时间在BMI类别之间无显著差异，与人口统计学特征和合并症无关。在插管队列中，住院事件和治疗没有差异，包括肾脏替代治疗、神经肌肉阻滞和俯卧位。在第1、3和7天，随着BMI的增加，通气率较高。调整后，插管队列中28或60天的无呼吸机天数（VFD）、气管造口术需求、医院LOS和基于BMI的出院处置无显著差异。在我们的COVID-19人群中，肥胖与发病率结局（如住院LOS、出院或VFD）之间没有关联。需要进一步的研究来阐明BMI对结果的影响的机制，这可能是人口依赖性的。
To evaluate the association between body mass index (BMI) and clinical outcomes other than death in patients hospitalised and intubated with COVID-19. This is a single-centre cohort study of adults with COVID-19 admitted to New York Presbyterian Hospital-Weill Cornell Medicine from 3 March 2020 through 15 May 2020. Baseline and outcome variables, as well as lab and ventilatory parameters, were generated for the admitted and intubated cohorts after stratifying by BMI category. Linear regression models were used for continuous, and logistic regression models were used for categorical outcomes. The study included 1337 admitted patients with a subset of 407 intubated patients. Among admitted patients, hospital length of stay (LOS) and home discharge was not significantly different across BMI categories independent of demographic characteristics and comorbidities. In the intubated cohort, there was no difference in in-hospital events and treatments, including renal replacement therapy, neuromuscular blockade and prone positioning. Ventilatory ratio was higher with increasing BMI on days 1, 3 and 7. There was no significant difference in ventilator free days (VFD) at 28 or 60 days, need for tracheostomy, hospital LOS, and discharge disposition based on BMI in the intubated cohort after adjustment. In our COVID-19 population, there was no association between obesity and morbidity outcomes, such as hospital LOS, home discharge or VFD. Further research is needed to clarify the mechanisms underlying the reported effects of BMI on outcomes, which may be population dependent.
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DOI：
10.1016/s2213-8587(21)00089-9
发表时间：
2021-06
期刊：
The lancet. Diabetes & endocrinology
影响因子：
--
作者：
Gao M;Piernas C;Astbury NM;Hippisley-Cox J;O'Rahilly S;Aveyard P;Jebb SA
通讯作者：
Jebb SA
影响因子：
39
作者：
Gupta, Shruti;Hayek, Salim S.;Leaf, David E.
通讯作者：
Leaf, David E.
影响因子：
9.6
作者：
Martino, Jenny L.;Stapleton, Renee D.;Heyland, Daren K.
通讯作者：
Heyland, Daren K.
影响因子：
8.8
作者：
Fumagalli, Jacopo;Santiago, Roberta R. S.;Zhao, Jing
通讯作者：
Zhao, Jing
影响因子：
10
作者：
Anzueto, A.;Frutos-Vivar, F.;Ferguson, N. D.
通讯作者：
Ferguson, N. D.