Enabling collaborative research using the Biomedical Informatics Research Network (BIRN)
Enabling collaborative research using the Biomedical Informatics Research Network (BIRN)
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DOI：
10.1136/amiajnl-2010-000032
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发表时间：
2011-07-01
影响因子：
6.4
通讯作者：
Kesselman, Carl
中科院分区：
文献类型：
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作者：
Helmer, Karl G.;Ambite, Jose Luis;Kesselman, Carl
随着生物医学技术的日益成熟，研究人员可以探测更微妙的影响，增加的要求是，小的影响的调查往往需要获取大量的数据。在生物医学中，这些数据通常在多个站点获取，然后在多个站点之间共享。要在研究人员之间传递数据，然后让更大的科学界可以访问，需要克服技术和社会学方面的障碍。生物医学信息学研究网络（BIRN）的目标是解决生物医学数据共享中固有的挑战。材料和方法BIRN工具分为“能力”，可用于数据管理，数据安全，信息集成和知识工程领域。BIRN关注用户驱动，并采用分层架构方法来促进基础设施的重用。BIRN工具被设计成模块化的，因此可以与现有的工具一起工作。BIRN用户可以选择最有用的功能，为他们的应用程序，而不必确保他们的项目符合单片architecture.Results BIRN已经实施了一个新的基于软件的数据共享基础设施，已投入使用在许多不同的领域内的生物医学。BIRN是积极参与外展到更广泛的生物医学界形成工作partnerships.Conclusion BIRN的使命是提供相关的能力和服务的生物医学研究界的数据共享。它通过建立伙伴关系和解决具体的、用户驱动的问题来做到这一点，这些问题的解决方案随后可供其他群体使用。
Objective As biomedical technology becomes increasingly sophisticated, researchers can probe ever more subtle effects with the added requirement that the investigation of small effects often requires the acquisition of large amounts of data. In biomedicine, these data are often acquired at, and later shared between, multiple sites. There are both technological and sociological hurdles to be overcome for data to be passed between researchers and later made accessible to the larger scientific community. The goal of the Biomedical Informatics Research Network (BIRN) is to address the challenges inherent in biomedical data sharing.Materials and methods BIRN tools are grouped into 'capabilities' and are available in the areas of data management, data security, information integration, and knowledge engineering. BIRN has a user-driven focus and employs a layered architectural approach that promotes reuse of infrastructure. BIRN tools are designed to be modular and therefore can work with pre-existing tools. BIRN users can choose the capabilities most useful for their application, while not having to ensure that their project conforms to a monolithic architecture.Results BIRN has implemented a new software-based data-sharing infrastructure that has been put to use in many different domains within biomedicine. BIRN is actively involved in outreach to the broader biomedical community to form working partnerships.Conclusion BIRN's mission is to provide capabilities and services related to data sharing to the biomedical research community. It does this by forming partnerships and solving specific, user-driven problems whose solutions are then available for use by other groups.