Application of super-resolution microscopy in mitochondria-dynamic diseases.
Application of super-resolution microscopy in mitochondria-dynamic diseases.
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DOI：
10.1016/j.addr.2023.115043
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发表时间：
2023-08
影响因子：
16.1
通讯作者：
Weiwei Zou;Li Yang;Hedong Lu;Min Li;Dongmei Ji;J. Slone;Taosheng Huang
中科院分区：
文献类型：
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作者：
Weiwei Zou;Li Yang;Hedong Lu;Min Li;Dongmei Ji;J. Slone;Taosheng Huang
传统的光学显微镜受时间和空间分辨率的限制，无法对细胞器和亚细胞器的超微结构进行成像。超分辨率显微镜的出现使之成为可能。在这篇综述中，我们将重点放在线粒体。本文综述了线粒体动力学的过程、调节线粒体形态的主要蛋白、与线粒体动力学相关的疾病。目的是将近年来发展起来的超分辨显微技术应用于线粒体的研究。通过提供合适的研究工具，我们将有助于促进该技术在深入阐明线粒体动力学相关疾病的发病机制、辅助诊断和开发治疗方法方面的应用。
Limited by spatial and temporal resolution, traditional optical microscopy cannot image the delicate ultra-structure organelles and sub-organelles. The emergence of super-resolution microscopy makes it possible. In this review, we focus on mitochondria. We summarize the process of mitochondrial dynamics, the primary proteins that regulate mitochondrial morphology, the diseases related to mitochondrial dynamics. The purpose is to apply super-resolution microscopy developed during recent years to the mitochondrial research. By providing the right research tools, we will help to promote the application of this technique to the in-depth elucidation of the pathogenesis of diseases related to mitochondrial dynamics, assistdiagnosis and develop the therapeutic treatment.