Resting neural activity distinguishes subgroups of schizophrenia patients
Resting neural activity distinguishes subgroups of schizophrenia patients
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DOI：
10.1016/j.biopsych.2004.09.013
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发表时间：
2004-12-15
影响因子：
10.6
通讯作者：
Van Heertum, R
中科院分区：
文献类型：
--
作者：
Malaspina, D;Harkavy-Friedman, J;Van Heertum, R
背景：精神分裂症的病因具有异质性。预计但未经证实，亚组在神经病理学方面会有所不同，并且神经影像学可能会揭示这些差异。最佳成像条件可能是在休息时，此时观察到的变异性比认知任务期间更大，这更一致地揭示了额叶下垂。我们之前证明了家族性和散发性精神分裂症患者之间的症状和生理差异，并假设这些群体会表现出不同的静息局部脑血流（rCBF）模式。方法：10 名家族性和 16 名散发性精神分裂症患者以及 9 名对照受试者在被动注视期间进行了单光子计算机断层扫描成像。图像在空间上归一化为 Talairach 坐标，并使用 SPM 分析组 rCBF 差异，Z 值阈值为 2.80，p > 0.001。结果：各亚组具有相似的年龄、性别、病程和药物治疗。散发性患者有额叶功能低下（前扣带皮层、副扣带皮层、左背外侧和眶下额叶），而家族性患者有左颞顶灌注不足；所有这些区域都显示出健康受试者的静息活动。两组的小脑/脑桥和海马旁回均过度灌注。在梭形中观察到散发患者的额外过度灌注；家族性精神分裂症患者的海马、齿状回、钩回、杏仁核、丘脑和壳核也存在过度灌注。结论：家族性和散发性精神分裂症患者的静息 rCBF 谱不同，支持某些亚组具有不同神经基础的假设。精神分裂症患者亚组之间不同的神经病理过程可能是先前静息影像学研究结果相互矛盾的原因。
Background: Schizophrenia is etiologically heterogeneous. It is anticipated, but unproven, that subgroups will differ in neuropathology and that neuroimaging may reveal these differences. The optimal imaging condition may be at rest, where greater variability is observed than during cognitive tasks, which more consistently reveal hypofrontality. We previously demonstrated symptom and physiological differences between familial and sporadic schizophrenia patients and hypothesized that the groups would show different resting regional cerebral blood flow (rCBF) patterns.Methods: Ten familial and sixteen sporadic schizophrenia patients and nine comparison subjects had single photon computed tomography imaging during passive visual fixation. Images were spatially normalized into Talairach coordinates and analyzed for group rCBF differences using SPM with a Z value threshold of 2.80, p >.001.Results: The subgroups had similar age, gender, illness duration, and medication treatment. Sporadic patients had hypofrontality (anterior cingulate, paracingulate cortices, left dorsolateral and inferior-orbitofrontal), whereas familial patients had left temporoparietal hypoperfusion; all of these regions show resting activity in healthy subjects. Both groups hyperperfused the cerebellum/pons and para parahippocampal gyrus; additional hyperperfusion for sporadic patients was observed in the fusiform; familial patients also hyperperfused the hippocampus, dentate, uncus, amygdala, thalamus, and putamen.Conclusions: Familial and sporadic schizophrenia patients bad cl different resting rCBF profiles, supporting The hypothesis that certain subgroups have distinct neural underpinnings. Different neuropathological processes among subgroups of schizophrenia patients may account for the prior contradictory results of resting imaging studies.