Cortex mediates multisensory but not unisensory integration in superior colliculus
Cortex mediates multisensory but not unisensory integration in superior colliculus
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DOI：
10.1523/jneurosci.3524-07.2007
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发表时间：
2007-11-21
影响因子：
5.3
通讯作者：
Stein, Barry E.
中科院分区：
文献类型：
--
作者：
Alvarado, Juan Carlos;Stanford, Terrence R.;Stein, Barry E.
会聚皮层的影响，从前外侧裂沟和头侧外侧上裂沟被证明有一个多感官特定的作用，在上级丘（SC）神经元的感觉信息的整合。这些观察结果是基于这些皮质SC预测的低温失活引起的变化。因此，尽管结果表明它们在整合SC对来自不同感官的刺激的反应中起着关键作用（即，视觉-听觉），它们在合成其对来自同一感觉（视觉-视觉）的刺激的反应方面没有发挥作用。即使在相同的多感觉神经元中，这一点也很明显。结果表明，非常不同的神经回路已经进化到对SC中跨模态和模态内刺激的组合进行编码，并且多感觉和单感觉整合的差异可能是由每个神经元功能输入的配置差异引起的，而不是由每个神经元的功能输入的配置差异引起的。神经元本身的任何固有差异。这些下行影响的特异性也很明显，因为它们以非常不同的方式影响对跨通道刺激成分的反应及其实际整合。此外，它们似乎只针对多感觉神经元，而不是它们的单感觉邻居。
Converging cortical influences from the anterior ectosylvian sulcus and the rostral lateral suprasylvian sulcus were shown to have a multisensory-specific role in the integration of sensory information in superior colliculus (SC) neurons. These observations were based on changes induced by cryogenic deactivation of these cortico-SC projections. Thus, although the results indicated that they played a critical role in integrating SC responses to stimuli derived from different senses (i.e., visual-auditory), they played no role in synthesizing its responses to stimuli derived from within the same sense (visual-visual). This was evident even in the same multisensory neurons. The results suggest that very different neural circuits have evolved to code combinations of cross-modal and within-modal stimuli in the SC, and that the differences in multisensory and unisensory integration are likely caused by differences in the configuration of each neuron's functional inputs rather than to any inherent differences among the neurons themselves. The specificity of these descending influences was also apparent in the very different ways in which they affected responses to the component cross-modal stimuli and their actual integration. Furthermore, they appeared to target only multisensory neurons and not their unisensory neighbors.