Effects of Hemodynamic Forces on the Vascular Differentiation of Stem Cells: Implications for Vascular Graft Engineering
Effects of Hemodynamic Forces on the Vascular Differentiation of Stem Cells: Implications for Vascular Graft Engineering
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DOI：
10.1007/978-1-4419-7835-6_10
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发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Li, Song
中科院分区：
文献类型：
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作者：
Diop, Rokhaya;Li, Song
尽管血管组织工程领域在过去的十年中取得了巨大的进步，但仍有一些并发症需要克服，才能制造出具有长期通畅性的生物兼容的小口径血管管道。干细胞和祖细胞是发展自体(或同种异体)、非血栓形成的血管移植物的潜在细胞来源，其机械性能与天然血管相当。然而，需要更好地了解机械力对干细胞和祖细胞的影响，才能正确地将这些细胞用于组织工程应用。在这一章中，我们讨论了目前对血流动力对成体干细胞、胚胎干细胞和祖细胞分化和功能的影响的理解。我们还回顾了干细胞和祖细胞在血管移植工程中的应用。
Although the field of vascular tissue engineering has made tremendous advances in the past decade, several complications have yet to be overcome in order to produce biocompatible small-diameter vascular conduits with long-term patency. Stem cells and progenitor cells represent potential cell sources in the development of autologous (or allogeneic), nonthrombogenic vascular grafts with mechanical properties comparable to native blood vessel. However, a better understanding of the effects of mechanical forces on stem cells and progenitor cells is needed to properly utilize these cells for tissue engineering applications. In this chapter, we discuss the current understanding of the effects of hemodynamic forces on the differentiation and function of adult stem cells, embryonic stem cells, and progenitor cells. We also review the use of stem cells and progenitor cells in vascular graft engineering.