TEMPERATURE CHANGES PRODUCED BY INJECTION OF CATECHOLAMINES AND 5-HYDROXYTRYPTAMINE INTO CEREBRAL VENTRICLES OF CONSCIOUS MOUSE
TEMPERATURE CHANGES PRODUCED BY INJECTION OF CATECHOLAMINES AND 5-HYDROXYTRYPTAMINE INTO CEREBRAL VENTRICLES OF CONSCIOUS MOUSE
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DOI：
10.1113/jphysiol.1967.sp008332
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发表时间：
1967-01-01
影响因子：
5.5
通讯作者：
HANDLEY, SL
中科院分区：
文献类型：
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作者：
BRITTAIN, RT;HANDLEY, SL
在将去甲肾上腺素、肾上腺素、异丙那林、多巴胺和5-羟色胺（5-HT）[去甲肾上腺素]注射到清醒小鼠的脑室中后，测定温度的变化。去甲肾上腺素（1-20毫克）和多巴胺（10-160微克）引起体温福尔斯。肾上腺素（1-20毫克）引起体温轻微和短暂的上升，随后下降。异丙肾上腺素（5-20 [mu]g）引起体温升高，体温过低仅在非常高剂量（200 [mu]g）的这种儿茶酚胺后发生。α-和β-肾上腺素能阻断剂酚妥拉明（> 2 μ g）和普萘洛尔（5 μ g）分别在注射到小鼠脑室时引起体温的福尔斯下降。由于[α]-和[β]-肾上腺素能阻滞剂的内在作用，特定药物拮抗作用研究有限。然而，获得的一些证据表明，去甲肾上腺素介导的影响，通过中央[α]型肾上腺素能受体。5-HT（10-160毫克）引起体温下降。本文讨论了吲哚胺和儿茶酚胺在体温调节功能方面的作用。
Changes in temperature were determined following injection of noradrenaline, adrenaline, iso-prenaline, dopamine and 5-hydroxytrptamine (5-HT) [norepinephrine] into the cerebral ventricles of the conscious mouse. Noradrenaline [epinephrine] (1-20 Mg) and dopamine (10-160 [mu]g) caused falls in body temperature. Adrenaline [epinephrine] (1-20 Mg) caused a slight and transient rise in body temperature followed by a fall. Isoprenaline (5-20 [mu]g) caused a rise in body temperature, hypothermia only occurring after very high doses (200 [mu]g) of this catecholamine. a- and 0-adrenergic blocking agents, phentolamine (> 2 Mg) and propranolol ( 5 Mg) respectively, caused falls in body temperature when injected into the cerebral ventricles of the mouse. Specific drug antagonism studies were limited owing to the intrinsic effects of the [alpha]- and [beta]-adrenergic blocking agents. However, some evidence was obtained to indicate that noradrenaline mediated its effects through a central [alpha]-type adrenergic receptor. 5-HT (10-160 Mg) caused a fall in body temperature. The action of this indoleamine and the catecholamines in regard to thermoregulatory function is discussed.