Regulation of phagosome maturation by signals from Toll-like receptors
Regulation of phagosome maturation by signals from Toll-like receptors
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DOI：
10.1126/science.1096158
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发表时间：
2004-05-14
期刊：
影响因子：
56.9
通讯作者：
Medzhitov, R
中科院分区：
文献类型：
--
作者：
Blander, JM;Medzhitov, R
在高等后生动物中，吞噬作用在宿主防御微生物病原体和清除凋亡细胞中至关重要。微生物细胞和凋亡细胞都以共同的途径从吞噬体递送到溶酶体进行降解。在这里，我们发现，Toll样受体（TLR）信号通路的细菌，而不是凋亡细胞的激活，调节吞噬在多个步骤，包括内化和吞噬体成熟。在TLR信号传导不存在的情况下，细菌的吞噬作用受损。观察到两种模式的吞噬体成熟，组成型和诱导型;其差异参与依赖于货物触发TLR信号传导的能力。
In higher metazoans, phagocytosis is essential in host defense against microbial pathogens and in clearance of apoptotic cells. Both microbial and apoptotic cells are delivered on a common route from phagosomes to lysosomes for degradation. Here, we found that activation of the Toll-like receptor (TLR) signaling pathway by bacteria, but not apoptotic cells, regulated phagocytosis at multiple steps including internalization and phagosome maturation. Phagocytosis of bacteria was impaired in the absence of TLR signaling. Two modes of phagosome maturation were observed, constitutive and inducible; their differential engagement depended on the ability of the cargo to trigger TLR signaling.