Prurigo pigmentosa: role of ICAM‐1 in the localization of the eruption
Prurigo pigmentosa: role of ICAM‐1 in the localization of the eruption
复制标题
色素性痒疹：ICAM-1 在皮疹定位中的作用
DOI：
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发表时间：
1991
影响因子：
10.3
通讯作者：
T. Nishikawa
中科院分区：
文献类型：
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作者：
Y. TERAKl;T. Shiohara;M. Nagashima;T. Nishikawa
本文对两例色素性黑热病皮损进行了免疫组化研究。真皮浸润中以CD 4+细胞为主，而表皮中的淋巴细胞主要为CD 8+细胞。大多数真皮和亲表皮淋巴细胞显示出淋巴细胞功能相关抗原1（LFA-1）的强烈表达。表皮中CD 1+细胞数量增加。炎性丘疹中角质形成细胞表达ICAM-1。在残留色素沉着区域仍观察到ICAM-1的局灶性表达，可以解释这些部位病变的复发。
Summary Immunohistochemical studies were carried out on the skin lesions of two cases of prurigo pigmentosa. There was a predominance of CD4+ cells in the dermal infiltrate, whereas those lymphocytes in the epidermis were mainly CD8 + cells. The majority of dermal and epidermotropic lymphocytes showed an intense expression of lymphocyte function‐associated antigen 1 (LFA‐1). The number of CD1+ cells was increased in the epidermis. There was intense expression of ICAM‐1 by keratinocytes in the erythematous papules. Focal expression of ICAM‐1 was still observed in the residual pigmented areas and could explain the recurrence of the lesions at these sites.
DOI：
10.1016/0022-202x(89)90193-0
发表时间：
1989-05
期刊：
The Journal of investigative dermatology
影响因子：
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作者：
Kay H. Singer;Debbi T. Tuck;Hugh A. Sampson;Russell P. Hall
通讯作者：
Kay H. Singer;Debbi T. Tuck;Hugh A. Sampson;Russell P. Hall