Effects of estrogens on cognition and brain morphology: Involvement of the cerebellum
Effects of estrogens on cognition and brain morphology: Involvement of the cerebellum
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DOI：
10.1016/j.maturitas.2005.11.002
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发表时间：
2006-06-20
期刊：
影响因子：
4.9
通讯作者：
Binetti, G.
中科院分区：
文献类型：
--
作者：
Ghidoni, R.;Boccardi, M.;Binetti, G.
目的：性类固醇激素与成人大脑的认知过程有关。在报告雌激素替代疗法（ERT）对认知有积极影响的研究中，最一致的证据是它可以增强言语记忆和视觉空间功能。在本研究中，我们研究了 ERT 对健康绝经后女性认知和大脑形态的影响，同时考虑到当前和过去 ERT 用户的区别。方法：参与者是从社区招募的绝经后非痴呆女性：ERT 用户为 40 名（当前用户 23 名，过去用户 17 名），从未使用过的为 43 名。40 名招募的受试者同意接受 3D 高分辨率 MRI （16 位当前用户、7 位过去用户和 17 位从未使用过）。参与者接受了 MMSE 和一系列测量记忆、语言、智力、注意力和视觉空间能力的神经心理学测试。结果：过去的用户组在四项测试中优于从未使用过的用户：Token 测试、WCST 类别、注意力矩阵和 Rey 延迟列表；在雷伊列表测试中，当前用户组的表现优于从未使用过的用户组。 ERT 用户的灰质体积主要在小脑，但顶叶和枕叶皮层也有增加。结论：ERT 的使用似乎可以提高语言、注意力和计划能力。有趣的是，对认知的有益影响主要是在过去的用户亚组中发现的。在这里，我们提出雌激素对小脑的营养作用可能是观察到的认知改善的原因。 (c) 2005 Elsevier Ireland Ltd. 保留所有权利。
Objectives: Sex steroid hormones are implicated in the cognitive processes of the adult brain. Among studies reporting a positive effect of estrogen replacement therapy (ERT) on cognition, the most consistent evidence is that it enhances verbal memory and visuospatial functions. In the present study we investigated the effect of ERT on cognition and on brain morphology in healthy postmenopausal women, taking into account the distinction in current and past ERT users.Methods: Participants were postmenopausal nondemented women recruited from the community: ERT users were 40 (23 current users, 17 past users), while never users were 43. Forty of recruited subjects gave consent to undergo 3D high resolution MRI (16 current users, 7 past users and 17 never users). Participants underwent MMSE and a battery of neuropsychological tests measuring memory, language, intelligence, attention and visuo-spatial abilities.Results: The past users group outperformed the never users in four tests: Token test, WCST categories, attentional matrices and Rey's delayed list; the current users group outperformed the never users in the Rey's list test. ERT users had greater grey matter volumes mainly in the cerebellum, but an increase was observed also in the parietal and occipital cortex.Conclusions: ERT use appears to improve linguistic, attentive and planning abilities. Interestingly, the beneficial effects on cognition were detected mainly in the past users subgroup. Here we propose that the trophic effect of estrogens on cerebellum might account for the observed improvement in cognition. (c) 2005 Elsevier Ireland Ltd. All rights reserved.