Regulation of β-endorphin and acth in brain by estradiol☆
Regulation of β-endorphin and acth in brain by estradiol☆
复制标题
雌二醇对脑内β-内啡肽和促肾上腺皮质激素的调节☆
DOI：
10.1016/0024-3205(85)90012-8
复制
发表时间：
1985
期刊：
影响因子：
6.1
通讯作者：
A. Frantz
中科院分区：
文献类型：
--
作者：
S. Wardlaw;Paulina Wang;A. Frantz
本实验观察了雌二醇对去卵巢大鼠脑内β-内啡肽(β-EP)和C-末端ACTH(CLIP)含量的影响。多巴胺是一种已知的垂体中间叶阿片黑素皮质素原(POMC)的抑制剂，被认为是雌二醇引起脑POMC变化的可能介质。动物接受1)生理盐水、2)硅橡胶雌二醇植入物或3)雌二醇植入物加氟哌啶醇1 mg/kg/d治疗1周或3周。治疗1周后，下丘脑β-EP含量与对照组相比无明显变化，但神经中间叶β-EP含量由治疗前的566±72增至942±73(P<；0.005)。3周后，雌二醇组下丘脑β-EP由3.96±0.28降至2.74±0.19pmol.005，C-末端ACTH值由3.78±0.33降至2.82±0.18pmol.氟哌啶醇不阻断雌二醇引起的下丘脑β-EP和C-末端ACTH量的下降。我们的结论是，雌激素降低了下丘脑β-EP和CLIP的含量，这种作用似乎不是由多巴胺介导的。
The effect of estradiol on the brain concentration of immunoreactive β-endorphin (β-EP) and C-terminal ACTH (CLIP) was studied in ovariectomized rats. Dopamine, a known inhibitor of pituitary intermediate lobe pro-opiomelanocortin (POMC), was examined as a possible mediator of the estradiol induced changes in brain POMC. Animals were treated for 1 or 3 weeks with either 1) saline; 2) silastic estradiol implants; or 3) estradiol implants plus haloperidol 1 mg/kg/day. After one week of treatment no significant change in hypothalamic β-EP content was noted in any group compared to the control level of 4.13 ± .33 (SEM) pmoles although in the neurointermediate lobe β-EP increased from 566 ± 72 to 942 ± 73 pomles after haloperidol (p < .005). After 3 weeks, however, hypothalamic β-EP decreased from 3.96 ± .28 to 2.74 ± .19 pmoles (p < .005) and C-terminal ACTH decreased from 3.78 ± .33 to 2.82 ± .18 pmoles (p < .02) in the estradiol treated rats. This estradiol induced decrease in the hypothalamic content of β-EP and C-terminal ACTH was not blocked by haloperidol. We conclude that estradiol lowers the hypothalamic content of β-EP and CLIP and that this effect does not appear to be mediated by dopamine.
促肾上腺皮质激素/内啡肽及相关肽的结构和生物合成。
影响因子：
20.3
作者：
Eipper,BA;Mains,RE
通讯作者：
Mains,RE