Characterization of knowledge-based volumetric modulated arc therapy plans created by three different institutions' models for prostate cancer
Characterization of knowledge-based volumetric modulated arc therapy plans created by three different institutions' models for prostate cancer
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DOI：
10.1016/j.rpor.2020.08.011
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发表时间：
2020-11-01
影响因子：
1.2
通讯作者：
Teshima, Teruki
中科院分区：
文献类型：
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作者：
Ueda, Yoshihiro;Monzen, Hajime;Teshima, Teruki
背景资料：本研究的目的是澄清预测因素的知识为基础的规划（KBP）模型的性能在体积调制弧治疗前列腺癌的保留器官的风险（OAR）。材料和方法：在三个机构，每个KBP模型进行了训练，超过20个库计划（LP）每个模型。为了验证每个KBP模型的表征，通过KBP系统计算了45个验证计划（VP）。分析了每个LP和VP的OAR体积和计划靶体积（PTV）与整个器官体积之间的重叠比率（V-重叠/V-整体）。评价了剂量-体积参数（V-90、V-75和V-50）与V-重叠/V-整体之间的回归线。LP的平均OAR剂量、V-90、V-75和V-50不一定与VP匹配。结果：在研究所A、B和C，在直肠和膀胱中，VP的剂量体积参数与V重叠/V整体强烈相关（R分别> 0.74、0.85和0.56）。除研究所B的直肠外，LP的回归线斜率与VP的回归线斜率一致。对于直肠的剂量-体积参数，VP与LP中回归线斜率的比值范围为0.51-1.26。在膀胱中，大多数比值小于1.0（平均值：0.77）。结论：对于每一个OAR，每个模型的V-重叠/V-整体的剂量学特征。剂量-体积参数与LP中OAR的V-重叠/V-整体之间的关系预测了KBP模型保留OAR的性能。(C)2020年大波兰癌症中心。Elsevier B. V.出版，保留所有权利。
Background: The aim of this study was to clarify factors predicting the performance of knowledge-based planning (KBP) models in volume modulated arc therapy for prostate cancer in terms of sparing the organ at risk (OAR).Materials and methods: In three institutions, each KBP model was trained by more than 20 library plans (LP) per model. To validate the characterization of each KBP model, 45 validation plans (VP) were calculated by the KBP system. The ratios of overlap between the OAR volume and the planning target volume (PTV) to the whole organ volume (V-overlap/V-whole) were analyzed for each LP and VP. Regression lines between dose-volume parameters (V-90, V-75, and V-50) and V-overlap/V-whole were evaluated. The mean OAR dose, V-90, V-75, and V-50 of LP did not necessarily match those of VP.Results: In both the rectum and bladder, the dose-volume parameters for VP were strongly correlated with V-overlap/V-whole at institutes A, B, and C (R > 0.74, 0.85, and 0.56, respectively). Except in the rectum at institute B, the slopes of the regression lines for LP corresponded to those for VP. For dose-volume parameters for the rectum, the ratios of slopes of the regression lines in VP to those in LP ranged 0.51-1.26. In the bladder, most ratios were less than 1.0 (mean: 0.77).Conclusion: For each OAR, each model made distinct dosimetric characterizations in terms of V-overlap/V-whole. The relationship between dose-volume parameters and V-overlap/V-whole of OARs in LP predicts the KBP models' performance sparing OARs. (C) 2020 Greater Poland Cancer Centre. Published by Elsevier B.V. All rights reserved.