Stem cell plasticity. Plasticity of epithelial stem cells in tissue regeneration.
Stem cell plasticity. Plasticity of epithelial stem cells in tissue regeneration.
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DOI：
10.1126/science.1242281
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发表时间：
2014-06-13
期刊：
影响因子：
--
通讯作者：
Fuchs E
中科院分区：
文献类型：
--
作者：
Blanpain C;Fuchs E
组织依靠干细胞进行稳态和修复。最近的研究表明，上皮干细胞的命运和多谱系潜力可以改变，这取决于干细胞是否存在于其驻留的小生境中并对正常组织的稳态作出反应，是否被动员以修复伤口，或者是否从其小生境中取出并在移植后挑战从头组织形态发生。在这篇综述中，我们讨论了不同群体的自然谱系限制的干细胞和定向祖细胞如何在生理和再生条件下表现出显着的可塑性和可逆性，并重新获得长期自我更新能力和多谱系分化潜力。我们还讨论了再生医学和癌症的细胞可塑性的影响。
Tissues rely upon stem cells for homeostasis and repair. Recent studies show that the fate and multilineage potential of epithelial stem cells can change depending on whether a stem cell exists within its resident niche and responds to normal tissue homeostasis, whether it is mobilized to repair a wound, or whether it is taken from its niche and challenged to de novo tissue morphogenesis after transplantation. In this Review, we discuss how different populations of naturally lineage-restricted stem cells and committed progenitors can display remarkable plasticity and reversibility and reacquire long-term self-renewing capacities and multilineage differentiation potential during physiological and regenerative conditions. We also discuss the implications of cellular plasticity for regenerative medicine and for cancer.