Herding Hippos: regulating growth in flies and man
Herding Hippos: regulating growth in flies and man
复制标题
DOI：
10.1016/j.ceb.2009.09.010
复制
发表时间：
2009-12-01
影响因子：
7.5
通讯作者：
McNeill, Helen
中科院分区：
文献类型：
--
作者：
Badouel, Caroline;Garg, Ankush;McNeill, Helen
细胞数量的控制需要细胞增殖和细胞死亡的协调调节。在果蝇和小鼠中的研究已经将Hippo激酶途径确定为控制细胞增殖和凋亡的关键信号传导途径。几项研究表明Hippo通路与多种癌症有关。最近的研究还揭示了Hippo通路在发育过程中控制细胞命运决定的作用。在这篇综述中，我们将介绍目前发展中的Hippo信号模型。我们将探讨海马通路在无脊椎动物和哺乳动物之间的差异，并专注于了解这种保守的途径是如何调节的最新进展。
Control of cell number requires the coordinate regulation of cell proliferation and cell death. Studies in both the fly and mouse have identified the Hippo kinase pathway as a key signaling pathway that controls cell proliferation and apoptosis. Several studies have implicated the Hippo pathway in a variety of cancers. Recent studies have also revealed a role for the Hippo pathway in the control of cell fate decisions during development. In this review, we will cover the current model of Hippo signaling in development. We will explore the differences between the Hippo pathway in invertebrates and mammals, and focus on recent advances in understanding how this conserved pathway is regulated.