Vascular injury induces expression of periostin - Implications for vascular cell differentiation and migration
Vascular injury induces expression of periostin - Implications for vascular cell differentiation and migration
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DOI：
10.1161/01.atv.0000149141.81230.c6
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发表时间：
2005-01-01
影响因子：
8.7
通讯作者：
Vary, CPH
中科院分区：
文献类型：
--
作者：
Lindner, V;Wang, QZ;Vary, CPH
Objective - Periostin mRNA is among the most strongly upregulated transcripts in rat carotid arteries after balloon injury. The goal of the present study was to gain insight into the significance of periostin in the vasculature.Methods and Results - Periostin expression after injury was localized to smooth muscle cells of the neointima and the adventitia. The expression of periostin in smooth muscle cells in vitro was not regulated by cytokines such as fibroblast growth factor-2 (FGF-2). In contrast, stimulation of MC3T3-E1 osteoblastic cells, NIH3T3 fibroblasts, or mesenchymal C3H10T1/2 cells with FGF-2 reduced periostin mRNA levels to
